Genetic and antigenic heterogeneity of infectious bronchitis virus in South America: implications for control programs.

Genetic and antigenic heterogeneity of infectious bronchitis virus in South America: implications for control programs. Avian Pathol. 2019 Feb 14;:1-28 Authors: Marandino A, Vagnozzi A, Craig MI, Tomás G, Techera C, Panzera Y, Vera F, Pérez R Abstract Infectious bronchitis virus (IBV) is a persistent sanitary problem for the South American poultry industry despite extensive vaccination. The IBV single-stranded RNA genome has high rates of mutation and recombination that generate a notorious virus variability. Since most IBV vaccines are type-specific, there is a need for a constant surveillance of the circulating lineages and knowledge about their genetic and antigenic properties. Here we present an integrative analysis that provides the pattern of genetic variation of the South American IBV strains and information about their antigenic characteristics. The genetic analysis was performed using the S1 complete coding sequences of all available South American strains, including newly obtained Argentine and Uruguayan field samples. Our phylogenetic and phylodynamic analyses evidence that three main lineages (GI-1, GI-11 and GI-16) are extensively circulating in South American flocks. Strains of the GI-1 lineage (Massachusetts-type) were detected in Argentina, Brazil, Chile and Colombia. The GI-11 lineage is an exclusive South American lineage that emerged in the 1950s, being at present the predominant lineage in Brazil and Uruguay. Th...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research