Relative quantification of plasma N-glycans in type II congenital disorder of glycosylation patients by mass spectrometry

ConclusionsOur methodology offers a feasible alternative to the current methods for CDG-II diagnosis by MS, which quantify glycan structures as fractions of the total summed signal across a mass spectrum, a strategy that lowers the variability of minor components. Moreover, given its sensitivity for less concentrated yet biologically relevant structures, it might assist the uncovering of novel diagnostic glycans in other CDG-II subtypes.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research