Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine

Publication date: January–February 2019Source: Mendeleev Communications, Volume 29, Issue 1Author(s): Vera V. Musiyak, Dmitry A. Gruzdev, Marionella A. Kravchenko, Diana V. Vakhrusheva, Galina L. Levit, Victor P. Krasnov, Valery N. CharushinNovel purin-6-yl, 2-aminopurin-6-yl and N-(purin-6-yl)glycyl derivatives of (S)-lysine and (S)-ornithine with free α-functional groups, as well as compounds containing N9-(2-hydroxy-ethoxy)methyl substituent in the purine core have been synthesized and tested for their inhibitory effect against Mycobacterium tuberculosis strains. Among the synthesized conjugates, one compound exhibiting a significant level of antimycobacterial activity has been found.Graphical abstract

Source: Mendeleev Communications - February 16, 2019 Category: Chemistry Source Type: research