Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease. Diabetes Metab. 2019 Feb 11;: Authors: Mantovani A, Zusi C, Sani E, Colecchia A, Lippi G, Zaza G, Valenti L, Byrne CD, Maffeis C, Bonora E, Targher G Abstract AIM: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD. METHODS: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Glomerular filtration rate (eGFRCKD-EPI) was estimated using the CKD-Epidemiology Collaboration equation, whilst albuminuria was measured with an immunonephelometric assay on morning spot urine samples. NAFLD was detected either by fatty liver index (FLI ≥ 60, n = 101) or by ultrasonography (n = 77). Genotyping was performed by TaqMan-Based RT-PCR system. RESULTS: - Eight patients had G/G, 41 G/C and 52 C/C PNPLA3 rs738409 genotypes, and 21 (20.8%) patients had CKD (eGFRCKD-EPI
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research

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ConclusionsThese findings indicate that the neural effects of AUD vary according to severity. Our results emphasize the utility of resting state fMRI as a neuroimaging biomarker for quantitative clinical evaluation of AUD.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsA clinically relevant model of PTA of venous stenosis in mice was created. PTA-treated vessels had increased lumen vessel area and WSS. The alterations in tissue markers of vascular remodeling, tissue hypoxia, proliferation, and cell death may be implications for future design of drug and device development.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 20 March 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Jean-Yves Jenny, Michel Bonnin, Didier Mainard, French Society of Hip and Knee Surgery (SFHG), French Society of Orthopedic Surgery and Traumatology (CNP-SoFCOT)
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Publication date: Available online 28 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Sadikah Behbehani, Tiffany Pham, Katie Kunze, Megan Wasson, Johnny YiABSTRACTStudy ObjectiveTo determine the incidence of a successful in-office voiding trial after minimally invasive hysterectomy.DesignA retrospective cohort study.SettingA tertiary care academic center.PatientsAll patients undergoing minimally invasive hysterectomies (vaginal, laparoscopic, or robotic) from January 2013 to July 2018 who have an unsuccessful voiding trial in the postoperative unit.InterventionsA voiding trial.Measurements and Main ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusions: The results indicated that probiotic food and supplement withLactobacillus andBifidobacterium could be used as interventions to improve specific anthropometric and biochemical outcomes among individuals withMetS. However, probiotic treatment alone could not reduce overall health risks. In addition, there were methodological drawbacks among reviewed studies, and further research is needed.Ann Nutr Metab 2019;74:224 –241
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Conclusions: BMI and WC may predict incident hypertension better than skinfold thickness, WHR, and WHTR in the Chinese population.Ann Nutr Metab 2019;74:215 –223
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Source: The Nurse Practitioner - Category: Nursing Tags: Feature: WOMEN'S HEALTH: DNP SPECIAL ISSUE Source Type: research
Authors: Medrano Navarro AL, Justel Enríquez A, Alameda Serrano J, Blasco Lamarca Y, Sáenz Abad D, Gimeno Orna JA Abstract BACKGROUND AND AIMS: Our aim was to assess the usefulness of KDIGO 2012 risk classification to predict total and cardiovascular mortality in type 2 diabetes mellitus (DM2). MATERIAL AND METHODS: Prospective cohort study that included DM2 patients. Clinical end-points were total and cardiovascular mortality. The main predictive variable was KDIGO risk classification, which is a combination of urinary albumin excretion and glomerular filtration rate. The predictive value was eva...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
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Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
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