Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies.

Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies. Curr Stem Cell Res Ther. 2019 Feb 12;: Authors: Hou X, Liu Y, Streuli I, Dallenback P, Dubuisson J, Ansaldi Y, Pluchino N Abstract Asherman's Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman's syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman's Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research. PMID: 30760192 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research

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Asherman syndrome (AS) is a condition defined by the presence of intrauterine adhesions (IUAs) resulting when the bona fide endometrium is replaced by fibrotic tissues, causing the uterine walls to adhere to one another and causing symptoms such as infertility, recurrent miscarriage, menstrual abnormalities, pelvic pain, and abnormal placentation. A successful treatment for AS requires a comprehensive approach and prevention seems to be paramount and starts by optimizing the diagnostic strategy (1 –3).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
AbstractAsherman ’s Syndrome (AS) is an acquired condition defined by the presence of intrauterine adhesions (IUA) that cause symptoms such as menstrual abnormalities, pelvic pain, infertility, recurrent miscarriage, abnormal placentation and attendant psychological distress. Classically, AS is considered an iatro genic disease triggered by trauma to the pregnant uterus. Different factors can cause the destruction of the endometrium, thus affecting the endometrial stem cell niche and creating IUAs. Curettage of the pregnant uterus appears to be the most common source of this destruction. Nevertheless, some AS cases h...
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