Influence of stanozolol administration together with resistance training on thyroid and some steroid hormones in male rats

AbstractAbuse of anabolic –androgenic steroids (AASs) can lead to numerous detrimental health effects on body systems. With the increased self-administration of these steroids during the last decades, endocrine modifications and hormonal alterations associated with them have become an important clinical issue. The purpose of this research was to study the influence of 8-week injections of different doses of stanozolol (ST) along with resistance training (RT) on the levels of thyroid and some steroid hormones. Twenty-four male Wistar rats were divided into four groups, equally: group 1, untrained + normal saline; group 2, RT + normal saline; group 3, RT + ST (2 mg/kg b.w.); and group 4, RT + ST (5 mg/kg b.w.). The exercise protocol consisted of three training sessions weekly by 5 repetitions/3 sets of stepping onto the ladder for 8 weeks. Weight was loaded at the tail of each rat. Blood concen trations of T3, T4, FT3, FT4, TSH, testosterone, and dihydrotestosterone were determined by immunoassay methods. TSH concentration decreased significantly in groups 3 and 4 as compared to control group and group 2. Significant increment of FT3 concentration was also observed in group 4 relative to groups 1 and 2. Dihydrotestosterone and testosterone concentrations decreased in groups 3 and 4 relative to controls, but the decrease was only statistically significant between groups 4 and 1. Moreover, exercise alone and also stanozolol treatment plus exercise induced no ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research