Combination of microneedles and microemulsions to increase celecoxib topical delivery for potential application in chemoprevention of breast cancer
Publication date: Available online 14 February 2019Source: International Journal of PharmaceuticsAuthor(s): Gabriela Mojeiko, Moacir de Brito, Giovanna C. Salata, Luciana B. LopesAbstractIn spite of the high incidence of breast cancer worldwide, there are few strategies for its chemoprevention, and they have limited adherence mainly due to their serious adverse effects. As a new approach for local breast cancer chemoprevention, we developed and optimized microemulsions for topical delivery of celecoxib to the breast skin, and evaluated their combination with microneedles to improve drug penetration for localization in the mammary tissue. Microemulsions containing water at 15% (ME-15), 29% (ME-29) and 60% (ME-60) were obtained and characterized. They were isotropic, displayed Newtonian behavior and particle size smaller than 100 nm. ME-15 and ME-29 increased transepidermal water loss (TEWL) compared to ME-60, and displayed stronger vascular toxicity, evidenced by hemorrhage and lysis in HET-CAM assays. ME-60 was more efficacious at increasing celecoxib cutaneous and percutaneous delivery (1.3-4-fold). Increasing the number of microneedle roller applications from 1 to 8 increased the number of skin punctures and TEWL; its association with ME-60 promoted no further increase in TEWL, but improved (1.6-4-fold) celecoxib cutaneous and percutaneous delivery. Microemulsion incorporation reduced celecoxib IC50 in MCF-7 cells (3.3-fold), suggesting that presence of formulation componen...
Authors: Liang C, Li N, Cai Z, Liang R, Zheng X, Deng L, Feng L, Guo R, Wei B Abstract At present, cancer is the first cause of death for humans, but early detection and treatment can help improve prognoses and reduce mortality. However, further development of carrier-assistant drug delivery systems (DDSs) is retarded by the aspects such as the low drug-carrying capacity, carrier-induced toxicity and immunogenicity, complex synthesis manipulation. The development of nanoscale drug delivery systems (NDDS) have been rapidly developed to address these issues. In this article, we used PLGA-PEG with good biocompatibilit...
Garlic and ginger pills can delay the healing of skin wounds when breast cancer spreads, expert says.
Findings seen among postmenopausal breast cancer patients regardless of activity level prediagnosis
Publication date: Available online 13 November 2019Source: American Journal of Preventive MedicineAuthor(s): Ethan O. Cohen, Olena O. Weaver, Hilda H. Tso, Karen E. Gerlach, Jessica W.T. Leung
Conclusions: Intra- and inter-provincial differences in the use of chemotherapy and acute care were observed. Understanding variations in care can help to identify gaps and opportunities for improvement and shared learnings. PMID: 31708656 [PubMed - in process]
Conclusions: Use of the 21-gene rs assay could be a cost-effective strategy for Ontario patients with estrogen receptor-positive, her2-negative early bca and 1-3 positive lns. PMID: 31708649 [PubMed - in process]
Might detection of mutations in CHEK2 be useful as a prognostic factor for patient response to treatment or potential for metastasis in breast cancer?Laboratory Medicine
In a new study, patients with HR+/HER2- early stage breast cancer completed 2 years of adjuvant palbociclib with a similar toxicity profile as that observed in the metastatic setting.Annals of Oncology