Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases.Graphical abstractCardamonin is a broad-spectrum inhibitor of NLRP3 inflammasome triggered by multiple stimuli. Moreover, the suppression of cardamonin on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Importantly, cardamonin improves the survival of mice suffering from LPS-induced lethal endotoxic shock, which is shown to be NLRP3 dependent.
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research