NSAID Kidney Risk Underestimated in Young, Active Adults NSAID Kidney Risk Underestimated in Young, Active Adults
High doses of prescribed NSAIDS are linked to increased risk of potentially preventable cases of acute kidney injury and chronic kidney disease in active young adults.Medscape Medical News
Publication date: Available online 18 March 2019Source: Stem Cell ResearchAuthor(s): Aditya S. Pawar, Alfonso Eirin, James D. Krier, John R. Woollard, Xiang-Yang Zhu, Amir Lerman, Andre J. van Wijnen, Lilach O. LermanAbstractIntroductionMesenchymal stem cells (MSCs) possess endogenous reparative properties and may serve as an exogenous therapeutic intervention in patients with chronic kidney disease. Cardiovascular risk factors clustering in the metabolic syndrome (MetS) might adversely affect cellular properties. To test the hypothesis that Mets interferes with MSC characteristics, we performed comprehensive comparison of...
Lower eGFR linked to elevated cancer risk relative to eGFR of 90 to 104 mL/min
Authors: Zhang S, Zhang W, Zhou G Abstract Stroke causes disability and high mortality, while it can be prevented by increasing public awareness of risk factors. The common known risk factors are hypertension, atrial fibrillation, heart failure, smoking, alcohol consumption, low physical activity, overweight and hypercholesterolemia. However, the deep understanding of risk factors is limited. Moreover, more risk factor emerges in recent years. To further increase the awareness of risk factors for stroke prevention, this review indicates the reasonable application of antihypertensive agents according to the age-depe...
ConclusionsHPR conversions occur in a significant proportion of CKD patients with maintenance doses of clopidogrel treatment post-PCI, and this conversion was not confined to CYP2C19 loss-of-function genotype carriers. Risk stratification for treatment adjustment in personalized antiplatelet therapy should be investigated in future research.Graphical abstract
Authors: Li C, Yap DYH, Chan G, Wen YB, Li H, Tang C, Li XM, Li XW, Chan TM Abstract OBJECTIVE: Renal thrombotic microangiopathy (TMA) is an uncommon pathological finding in lupus nephritis (LN), and its clinical significance remains to be defined. METHODS: 24 patients with lupus nephritis (LN) and renal TMA were selected from a retrospective review of 677 biopsy-proven LN patients, and compared with 48 LN Controls without TMA (in 1:2 ratio) matched according to demographics and treatments. RESULTS: Renal TMA was noted in 3.5% of kidney biopsies of LN. TMA was associated with a higher prevalence of anti-Ro ...
An estimated 14.8% of adults have chronic kidney disease (CKD).1 Diabetic kidney disease (DKD) is classified according to the presence of microalbuminuria or macroalbuminuria.2 Of the 30 million US individuals with diabetes, those who met any criteria for DKD is estimated at 26.2%. Using 2010 census data, this translates to a prevalence of approximately 8.2 million people with any DKD, including 4.6 million people with albuminuria, 1.9 million people with macroalbuminuria, 4.5 million people with reduced estimated glomerular filtration rate (eGFR), and 0.9 million people with severely reduced eGFR.
Advanced kidney disease is often considered a relative contraindication to LVAD implantation and many implanting centers view stage 4 and 5 chronic kidney disease (CKD) as an absolute contraindication. We sought to analyze the impact of CKD at the time of LVAD implant on outcomes.
Acute Kidney Injury (AKI) is known to be associated with poor outcomes in patients undergoing Left ventricular assist device (LVAD) implantation. We sought to determine the trends and predictors of AKI in this patient population.
A retrospective multi-center cohort study was conducted, including all patients undergoing LVAD implantation. The Chronic Kidney Disease Epidemiology collaboration equation was used to determine the estimated glomerular filtration rate. Creatinine measurements were collected over a 2-year follow-up period. Patients stratification was based on their pre-operative CKD stage.
This study was conducted to determine the rate of AKI and CKD post LT and recovery of AKI while using IVFK.