Impact of health care –associated community-onset cellulitis in Korea: a multicenter study

AbstractWe conducted a multicenter study to determine the clinical and microbiological characteristics of health care –associated (HCA) cellulitis in Korea. We retrospectively reviewed the medical records of patients who had been diagnosed with community-onset cellulitis. Of the 2208 cellulitis patients, 232 (10.5%) had HCA cellulitis, 1243 (56.3%) patients were hospitalized, and 15 (0.7%) died in hospital. Compa red with community-acquired (CA) cellulitis, patients with HCA cellulitis were older and more frequently presented with comorbidity and septic shock. A total of 355 microorganisms were isolated from 314 patients (14.2%).Staphylococcus aureus (134 isolates) was the most common organism, followed byStreptococcus spp. (86 isolates) and Gram-negative fermenters (58 isolates). Methicillin-resistantS. aureus (MRSA) accounted for 29.1% (39/134) ofS. aureus infections. None of the Gram-negative fermenters were resistant to carbapenem. The antibiotic susceptibility pattern of isolated microorganisms was not different between HCA and CA cellulitis. In patients with HCA cellulitis,S. aureus (11.2% [26/232] vs. 5.5% [108/1976],p = 0.001), including MRSA (4.3% [10/232] vs. 1.5% [29/1976],p = 0.003) and Gram-negative fermenters (6.0% [14/232] vs. 2.3% [44/1976],p = 0.002), were more common causative organisms than in CA-cellulitis patients. Age ≥ 65 years, septic shock, and HCA infection were statistically significant factors associated with in-hospital mortalit...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research