Se Regulates the Contractile Ability of Uterine Smooth Musclevia Selenoprotein N, Selenoprotein T, and Selenoprotein Win Mice.

In this study, genes related to SelN, SelT, and SelW expression in uterine smooth muscle cells were investigated. The results showed that the Se concentration had an effect on the expression of SelN, SelT, and SelW in uterine smooth muscle cells. Se influences the release of Ca2+ through SelN, SelT, and SelW, which changes the expression of MLCK and then affects uterine smooth muscle contractions. The three selenoproteins SelN, SelT, and SelW play a very important role in uterine smooth muscle contractions, and the absence of any of these proteins affects the contractility of the uterus.
PMID: 30756291 [PubMed - as supplied by publisher]

Source: Biological Trace Element Research - February 12, 2019 Category: Biology Authors: Wang FH, Peng X, Chen Y, Wang Y, Yang M, Guo MY Tags: Biol Trace Elem Res Source Type: research