Adverse Reactions to Fluorescein Angiography: A Comprehensive Review of the Literature

We reviewed literature on adverse reactions to intravenous fluorescein angiography (IVFA) using PubMed and found 78 articles in English from 1961-2017. The reported rates of adverse reactions were overall 0.083-21.69%, separated into mild (1.24-17.65%), moderate (0.2-6%), and severe (0.04-0.59%). There were 1:100,000 to 1:220,000 deaths. Fluorescein concentration, volume injected, speed of injection, temperature, and contaminates were not correlated with the incidence of reactions. Patient characteristics including other comorbid diseases, allergy history, age, race, and gender showed only an increased rate of reaction in patients with a history of reaction to fluorescein.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Tags: Diagnostic and surgical techniques Source Type: research