Bioactive constituents from marine-derived Streptomyces sp. NB-A13

Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Qian-qian Wang, Biao Zhou, Yuan-yuan Ji, Hao-jian Zhang, Zhong-jun Ma, Li Shen, Wan-jing DingAbstractSix new anthracyclines (1-6) were obtained by the investigation of the solid fermented extract of a marine-derived Streptomyces sp. NB-A13. The structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, HRESIMS, UV and IR. The absolute configurations of compounds 1-5 were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. Among the isolates, four compounds (2, 3, 5 and 6) showed moderate cytotoxic activity against PC3 cells (prostate cancer cells) with IC50 values of 7.0 ± 0.3 μM, 0.92 ± 0.05 μM, 2.1 ± 0.7 μM and 9.8 ± 0.7 μM, respectively.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research