Bioassay-guided isolation of lignanamides with potential anti-inflammatory effect from the roots of Solanum melongena L

Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Bing-You Yang, Xin Yin, Yan Liu, Hong-Liang Ye, Mei-Ling Zhang, Wei Guan, Hai-Xue KuangAbstractThree new lignanamides, melongenamide E–G (1–3), together with fourteen known analogues (4-17) were isolated by bioassay-guided fractionation from the roots of Solanum melongena L. The chemical structures of all isolated compounds were elucidated using 1D and 2D NMR experiments and by comparing their spectroscopic and physical data with values from the published literature. These isolated compounds were tested for their inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in a macrophage cell line RAW 264.7. Compounds 1–7 and 10 showed moderate inhibition of NO production with IC50 values ranging from 10.6 ± 2.3 to 33.7 ± 2.7 μM.Graphical abstract

Source: Phytochemistry Letters - February 14, 2019 Category: Chemistry Source Type: research