Boehringer Ingelheim and Lilly announce the CAROLINA(R) cardiovascular outcome trial of Tradjenta(R) met its primary endpoint of non-inferiority compared with glimepiride
Tradjenta (linagliptin) demonstrated no increased cardiovascular risk compared with glimepiride in adults with type 2 diabetes and cardiovascular risk With a median follow-up of more than 6 years, CAROLINA adds evidence to the long-term safety profile o... Biopharmaceuticals, Endocrinology Eli Lilly, Boehringer Ingelheim, Tradjenta, linagliptin, diabetes
Publication date: Available online 27 March 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Roberto Laza-Cagigas, Shirley Chan, Daniel Sumner, Tarannum Rampal
RARITAN, NJ, March 28, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced the VOYAGER PAD study met its primary efficacy and principal safety endpoints, demonstrating the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily) plus aspirin (100 mg once daily) was superior to aspirin alone in reducing the risk of major adverse limb and cardiovascular (CV) events by 15 percent in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization, with similar rates of TIMI major bleeding. VOYAGER PAD is the only study to show a significant benefit...
Conclusions: These results demonstrated that there was no evidence of a relationship between ApoE and PAD. PMID: 32211081 [PubMed - in process]
Conclusions: This study supports that high uric acid concentrations are associated with increased diabetes risk, independent of other known risk factors. These data expand on well-established associations between SUA level and metabolic syndrome, and extend the link to the future risk of type 2 diabetes.
In conclusion, our case-control and meta-analysis studies did not indicate an association between the analyzed UCP2 polymorphisms and DKD.
ABSTRACT: Type 2 diabetes mellitus is an increasingly urgent public health issue in the United States. Prevention through early detection and education can help decrease the prevalence and complications of the disease. A nursing faculty member and a postgraduate year one pharmacy resident collaborated to provide diabetes screening and education at a local festival in rural Alabama. The prevalence of diabetes in Alabama is approximately 1.6 times higher than the national average. A glycated hemoglobin (HbA1c) test is the gold standard for diabetes diagnosis and is relatively quick and inexpensive. At the event, 38 partici...
Condition: Diabetes Mellitus, Type 2 Intervention: Other: Exposure factors Sponsor: First Affiliated Hospital Xi'an Jiaotong University Not yet recruiting
Condition: Gestational Diabetes Interventions: Drug: Liraglutide 6 MG/ML [Victoza]; Drug: Placebos Sponsor: Turku University Hospital Recruiting
Publication date: Available online 26 March 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Abbas Ali Mansour, Nassar Taha Yaseen Alibrahim, Haider Ayad Alidrisi, Ali Hussain Ali Alhamza, Ammar Mohammed Saeed Abdullah Almomin, Ibrahim Abbood Zaboon, Muayad Baheer Kadhim, Rudha Naser Hussein, Hussein Ali Nwayyir, Adel Gassab Mohammed, Dheyaa Kadhim Jabbar Al-Waeli, Ibrahim Hani Hussein, FDEMC Study group