Valorization of crude glycerol, residue deriving from biodiesel-production process, with the use of wild-type new isolated Yarrowia lipolytica strains: production of metabolites with pharmaceutical and biotechnological interest.

Valorization of crude glycerol, residue deriving from biodiesel-production process, with the use of wild-type new isolated Yarrowia lipolytica strains: production of metabolites with pharmaceutical and biotechnological interest. Curr Pharm Biotechnol. 2019 Feb 11;: Authors: Sarris D, Sampani Z, Rapti A, Papanikolaou S Abstract Crude glycerol (Glol), used as substrate for screening eleven natural Yarrowia lipolytica strains in shake-flask experiments. Aim of this study was to assess the ability of the screened strains to produce biomass (dry cell weight; X), lipid (L), citric acid (Cit), mannitol (Man), arabitol (Ara) and erythritol (Ery), compounds presenting pharmaceutical and biotechnological interest, in glycerol-based nitrogen-limited media, in which initial glycerol concentration had been adjusted to 40 g/L. Citric acid may find use in biomedical engineering (i.e. drug delivery, tissue engineering, bioimaging, orthopedics, medical device coating, wound dressings). Polyols are considered as compounds with non-cariogenic and less calorigenic properties as also with low insulin-mediated response. Microbial lipids containing polyunsaturated fatty acids (PUFA) are medically and dietetically important (selective pharmaceutical and anticancer properties, aid fetal brain development, the sight function of the eye, hormonal balance and the cardio-vascular system, prevent reasons leading to type-2 diabetes, present healing and anti-inflammatory effects). All ...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research

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Authors: Udler MS, McCarthy MI, Florez JC, Mahajan A Abstract Over the last decade, there have been substantial advances in the identification and characterization of DNA sequence variants associated with individual predisposition to type 1 and type 2 diabetes. As well as providing insights into the molecular, cellular and physiological mechanisms involved in disease pathogenesis, these risk variants, when combined into a polygenic score, capture information on individual patterns of disease predisposition that have the potential to influence clinical management. In this review, we describe the various opportunitie...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
TYPE 2 diabetes affects over four million people in the UK and those numbers are growing everyday. Lifestyle plays a huge role in developing the condition and with obesity at an all time high, a new NHS backed app hopes to get Britons healthier and reduce their risk of developing the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionsRemission of type 2 diabetes 5 years after bariatric surgery was associated with improvements in albuminuria and stabilized prognostic risk for CKD, but not with eGFR. Lower kidney function and greater prognostic risk at the time of bariatric surgery was linked to a lower likelihood of diabetes remission. These results highlight the need to identify the mechanisms through which bariatric surgery may delay the long-term progression of CKD in type 2 diabetes.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Publication date: August 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 8Author(s): Ilaria Calabrese, Marilena Vitale, Maria Masulli, Angela Albarosa Rivellese, Gabriele Riccardi, Olga Vaccaro
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
ConclusionThere is a need to increase the awareness of MS among the PHC Physicians. More training programs need to be planned. A better awareness among primary care physician is warranted for an early diagnosis and effective management of MS in Saudi Arabia.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 19 July 2019Source: Canadian Journal of DiabetesAuthor(s): P. Khanna, L. Chow, E. Brydges, K. Anukum, S. Liu, J.L. Mahon, T. Joy, R. McManusAbstractPregnancies complicated by diabetes are increasingly frequent. The Endocrine and Pregnancy Clinic [EPC] at St Joseph’s Health Care London is the stable, local provider of all outpatient pregnancy diabetes care, thereby providing an opportunity to document patient characteristics with time.MethodsEPC charts were reviewed for: 2000-2002; 2010-2012; 2014-2016 documenting DM type (T1DM, T2DM, GDM); age; weight; year/week of DM diagnosis; med...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
TYPE 2 diabetes is characterised by the bodies inability to metabolise sugar . An evening snack could wreak havoc on a diabetics blood levels. What is the best snack to eat in the evening?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Introduction: To analyze the relationship between adherence to the Mediterranean diet, glucose control, body weight and major cardiovascular (CV) risk factors in people with type 2 diabetes mellitus (T2DM) and to evaluate the impact thereon of specific foods, typical of this dietary pattern.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Introduction: To date, the Mediterranean diet is the first therapeutic approach for patients with type 2 diabetes mellitus (T2DM). Conversation Maps ™ (C-Maps™) are interactive educational tools on diabetes, with a strong visual impact. The “Healthy Eating and Keeping Active” provides for a healthy eating style and physical activity in order to better handle diabetes. The aim of the study has been to evaluate the impact on changing eatin g habits and increasing the knowledge of the disease with the group therapeutic education through the use of C-Maps™ tool.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Conclusion: We studied 81 type 2 diabetic patients, with established cardiovascular disease, consecutively admitted to our outpatient clinic in the Division of Diabetes of La Paz Hospital. We collected clinic and demographic data, ABI and TBI were measured and at the same time a carotid Doppler ultrasound was performed. Multiple linear regression analysis was used to investigate the association of ABI and TBI with carotid disease. We found a negative correlation between TBI and internal carotid artery peak systolic velocity (ICA PSV) (r = -0,300, p= 0,007), common carotid artery resistance index (CCA RI) (r = -0,232, p= 0,...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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