Valorization of crude glycerol, residue deriving from biodiesel-production process, with the use of wild-type new isolated Yarrowia lipolytica strains: production of metabolites with pharmaceutical and biotechnological interest.

Valorization of crude glycerol, residue deriving from biodiesel-production process, with the use of wild-type new isolated Yarrowia lipolytica strains: production of metabolites with pharmaceutical and biotechnological interest. Curr Pharm Biotechnol. 2019 Feb 11;: Authors: Sarris D, Sampani Z, Rapti A, Papanikolaou S Abstract Crude glycerol (Glol), used as substrate for screening eleven natural Yarrowia lipolytica strains in shake-flask experiments. Aim of this study was to assess the ability of the screened strains to produce biomass (dry cell weight; X), lipid (L), citric acid (Cit), mannitol (Man), arabitol (Ara) and erythritol (Ery), compounds presenting pharmaceutical and biotechnological interest, in glycerol-based nitrogen-limited media, in which initial glycerol concentration had been adjusted to 40 g/L. Citric acid may find use in biomedical engineering (i.e. drug delivery, tissue engineering, bioimaging, orthopedics, medical device coating, wound dressings). Polyols are considered as compounds with non-cariogenic and less calorigenic properties as also with low insulin-mediated response. Microbial lipids containing polyunsaturated fatty acids (PUFA) are medically and dietetically important (selective pharmaceutical and anticancer properties, aid fetal brain development, the sight function of the eye, hormonal balance and the cardio-vascular system, prevent reasons leading to type-2 diabetes, present healing and anti-inflam...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research