Real-time respiratory triggered four dimensional cone-beam CT halves imaging dose compared to conventional 4D CBCT.

Real-time respiratory triggered four dimensional cone-beam CT halves imaging dose compared to conventional 4D CBCT. Phys Med Biol. 2019 Feb 12;: Authors: Cooper BJ, O'Brien RT, Shieh CC, Keall PJ Abstract Four dimensional cone-beam computed tomography (4D CBCT) improves patient positioning and the accuracy of radiation therapy for patients with mobile tumours. Generally, 4D CBCT requires many hundreds of x-ray projections to measure target trajectories and the imaging frequency is not adapted to the patient's respiratory signal resulting in over-sampling. In contrast, respiratory triggered 4D CBCT (RT 4D CBCT) is an acquisition technique that has been experimentally implemented and has shown to reduce the number of x-ray projections and thus 4D CBCT dose with minimal impact on image quality. The aim of this work is to experimentally investigate RT 4D CBCT in situ and measure target trajectory mean position, image quality and imaging dose from this new approach. A commercially available phantom with programmable target motion was programmed with nine target trajectories derived from patient-measured respiratory traces known to span the range of image quality when used for 4D CBCT reconstruction. 4D CBCT datasets were acquired for each target trajectory using the RT 4D CBCT acquisition technique and the conventional 4D CBCT acquisition technique. From the reconstructed 4D CBCT datasets, target trajectory mean positions, imaging dose and image quality metri...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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Conclusion: PSCCT is a rare but aggressive malignancy of the head and neck. Histopathologic and immunohistochemical evaluations are essential for diagnosis. While locoregional surgery and radiation therapy may improve the length of survival, the prognosis of patients with PSCCT is poor. Physicians should be mindful of this unique but deadly disease process, as early diagnosis and rapid treatment initiation are essential to optimize treatment outcomes. PMID: 31528145 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
AbstractA large intra-cardiac tumor from the right ventricle to pulmonary trunk was detected by contrast-enhanced computed tomography and transthoracic echocardiography in a 59-year-old woman with progressive dyspnea on effort and acute congestive right-sided heart failure. Emergent surgical management was performed with cardiopulmonary bypass under cardiac arrest, however, tumor resection was incomplete, because it originated from the interventricular septum. Concomitant tricuspid valve replacement using a bioprosthesis was required due to the involvement of the septal leaflet of the tricuspid valve. Although large pulmon...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractMucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary gland. However, reports of high grade transformation in MEC are extremely rare, and only two cases have so far been described. Recent development of salivary gland pathology revealed recurrent gene rearrangements in many kinds of tumors, includingMAML2 fusion of MEC. To date, theMAML2 status of high grade transformed MEC has not been studied. Here we report the first case of minor salivary gland origin high grade transformation in MEC with aMAML2 break apart FISH study. A 73-year-old woman presented with a 1-month history of left mand...
Source: Head and Neck Pathology - Category: Pathology Source Type: research
Conclusions: VMAT plan can reduce the risk of secondary malignancy while treating different sites of cancer. VMAT is the most appropriate technique than IMRT, especially in the treatment of large tumor volume. Special attention has to be given, especially while treating women and children.
Source: Journal of Medical Physics - Category: Physics Authors: Source Type: research
ConclusionAdrenal neuroblastoma in elderly adults is a very rare disease with sparse data available in the literature. Early stage disease could be managed by surgical resection alone. However, the prognosis is significantly worse than that observed in pediatric patients. Further research focusing on tumor biology and therapy for this rare malignancy in adults may help to improve disease outcome.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
CONCLUSION: Quantitative volumetric analysis of the pattern of extraocular muscle volume reduction and exophthalmos length reduction in response to radiation therapy will allow clinicians to better understand the effect of radiotherapy on Graves' ophthalmopathy. PMID: 31496266 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
Restaging computed tomography scans of the chest/abdomen/pelvis are needed to assess extracranial disease  burden and determine whether there is an accessible lesion for biopsy (if systemic therapy will be considered).1 Furthermore, this serves to rule out the potential of another primary that may warrant whole-brain radiation therapy consideration (ie, small cell lung cancer).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
ConclusionsInjection of a liquid fiducial marker for esophageal cancer radiation therapy is technically feasible with no adverse events identified. Volumes of>0.05 mL have an appropriate visibility on CT, CBCT, and MRI, with an excellent positional stability. Liquid fiducial markers are therefore promising for use in image guided radiation therapy.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
DiscussionThe goal of this trial is a further reduction of the radiation dose in patients with nodal early-stage FL showing a good response to a combination of LDRT and anti-CD20 immunotherapy and a comparison with the currently published MIR trial.Trial registrationEudraCT number: 2016-002059-89. ClinicalTrials.gov identifier:NCT03341520.
Source: Trials - Category: Research Source Type: clinical trials
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