Comorbid Immune-Mediated Diseases in IBD Comorbid Immune-Mediated Diseases in IBD

How prevalent are coexisting immune-mediated diseases in patients with inflammatory bowel disease, and how might they impact prognosis?Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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Beatriz P êgo, Cesonia A. Martinusso, Claudio Bernardazzi, Beatriz Elias Ribeiro, Aline Fernandes de Araujo Cunha, Jacilene de Souza Mesquita, Hayandra F. Nanini, Marcelo Pelajo Machado, Morgana T. L. Castelo-Branco, Marta Guimarães Cavalcanti, Heitor S. P. de Souza
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Lourdes Rocamora-Reverte, Selma Tuzlak, Laura von Raffay, Marcel Tisch, Heidi Fiegl, Mathias Drach, Holger M. Reichardt, Andreas Villunger, Denise Tischner, G. Jan Wiegers
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Is it efficacious and cost-effective to continue aminosalicylates in patients with ulcerative colitis who have been escalated to immunosuppressants, biologics, or oral small molecules?Alimentary Pharmacology &Therapeutics
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Gastroenterology Journal Article Source Type: news
Authors: Seidler U, Nikolovska K Abstract SLC26 family members are multifunctional transporters of small anions, including Cl- , HCO3 - , sulfate, oxalate, and formate. Most SLC26 isoforms act as secondary (coupled) anion transporters, while others mediate uncoupled electrogenic transport resembling Cl- channels. Of the 11 described SLC26 isoforms, the SLC26A1,2,3,6,7,9,11 are expressed in the gastrointestinal tract, where they participate in salt and water transport, surface pH-microclimate regulation, affect the microbiome composition, the absorption, and secretion of oxalate and sulfate, and other functions that...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Kato J, Yoshida T, Hiraoka S Abstract INTRODUCTION: Prediction of treatment outcome and clinical relapse in patients with inflammatory bowel disease (IBD), either ulcerative colitis (UC) or Crohn's disease (CD), is particularly important because therapeutics for IBD are not always effective and patients in remission could frequently relapse. Because undergoing endoscopy for the purpose is sometimes invasive and burdensome to patients, the performance of surrogate biomarkers has been investigated. Areas covered: We particularly featured the performance of patient symptoms, blood markers including C-reactive...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
ConclusionsAcross 1  year, we observed gaps in the screening and treatment of anemia in IBD. Although screening rates did not improve, the ACP appeared to reduce missed opportunities for iron therapy by about half. Most importantly, this was associated with an overall decrease in anemia prevalence. Future refinements to the ACP should be focused on enhanced screening and follow-up.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Authors: Isolauri E, Rautava S, Salminen S, Collado MC Abstract Recent demonstrations link clinical conditions, phenotypes alternating from inflammatory bowel disease, obesity, and allergic diseases to neurodevelopmental disorders, to aberrant gut microbiota composition. This has led to a growing interest in host-microbe crosstalk, characterizing the healthy microbiome and modifying its deviations at an early age. The rationale arises from the recognition of the intimate interrelationship between diet, immune system, and microbiome and the origins of human diseases. Before satisfactory preventive measures can be pu...
Source: Nestlee Nutrition Institute Workshop Series - Category: Nutrition Tags: Nestle Nutr Inst Workshop Ser Source Type: research
Authors: van den Elsen LWJ, Rekima A, Verhasselt V Abstract Gut immune function conditions the development of local and systemic diseases that result from defects in immune regulation, such as inflammatory bowel disease, allergy and obesity. As epidemiological studies support the developmental origin of health and disease, deciphering the critical factors modulating gut immune development should allow the advance of primary prevention strategies specifically adapted to the early-life immune system. Here, we will review gut mucosal immunity development and cover in more detail the recent understanding of the impact ...
Source: Nestlee Nutrition Institute Workshop Series - Category: Nutrition Tags: Nestle Nutr Inst Workshop Ser Source Type: research
CONCLUSIONS: TNFR1 promotes epithelial homeostasis and regulates commensal exposure. T he lack of TNFR1 accelerates the onset and severity of IBD in the absence of tolerogenic signaling (i.e., lack of IL-10). Il10-/- Tnfr1-/- mice may serve as a valuable model of very-early-onset IBD (VEO-IBD).
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
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