Increase in post-reperfusion sensitivity to tissue plasminogen activator-mediated fibrinolysis during liver transplantation is associated with abnormal metabolic changes and increased blood product utilisation.

DISCUSSION: StF is a transient event that resolves within 2 hours of graft reperfusion and is associated with increased blood product use. This phenomenon correlates with derangements in citric acid cycle, purine and amino acid metabolism. Future research is needed to determine whether these metabolites are biomarkers or mechanistically linked to increased sensitivity to t-PA-mediated fibrinolytic activity following graft reperfusion.
PMID: 30747704 [PubMed - as supplied by publisher]

Source: Blood Transfusion - February 4, 2019 Category: Hematology Authors: Moore HB, D'alessandro A, Moore EE, Wither M, Lawson PJ, Huebner BR, Hansen K, Choudhury R, Nydam TL Tags: Blood Transfus Source Type: research