Simvastatin and other inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase of Ustilago maydis (Um-Hmgr) affect the viability of the fungus, its synthesis of sterols and mating.
CONCLUSIONS: Given our results we believe U. maydis is a valid model for studying synthetic inhibitors with lipid-lowering or antifungal activity. Additionally, we propose the Hmgr enzyme as an alternative molecular target to develop compounds for treating both phytopathogenic and pathogenic human fungi.
PMID: 30745018 [PubMed - as supplied by publisher]
Source: Revista Iberoamericana de Micologia - Category: Biology Authors: Rosales-Acosta B, Mendieta A, Zúñiga C, Tamariz J, Hernández Rodríguez C, Ibarra-García JA, Villa-Tanaca L Tags: Rev Iberoam Micol Source Type: research
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