New Imaging Method Measures Efficacy of Breast Cancer Therapy

Researchers from the University of Wisconsin School of Medicine and Public Health have discovered a new way to measure the efficacy or failure of hormone therapy for breast cancer patients. A study detailing the findings was published in the February issue of The Journal of Nuclear Medicine. The findings showed that positron emission tomography (PET) imaging with 18F-fluorofuranylnorprogesterone (18F-FFNP) has been found to successfully measure changes in progesterone receptor (PR) levels resulting from a short-course estrogen treatment, also known as an estradiol challenge. Estrogen-receptor (ER)-positive breast cancer is the most common class of breast cancer, affecting nearly 70% of patients. By participating in an estradiol challenge, physicians can determine the likelihood of potential benefit of hormonal therapies targeting ER for individual patients. As such, several PET tracers have been developed to monitor and analyze changes in the PR level during therapy. "Typically, anatomic size and proliferation biomarkers are analyzed to determine endocrine sensitivity," Amy Fowler, MD, PhD, assistant professor, Section of Breast Imaging, Department of Radiology, University of Wisconsin-Madison, said in a release. "However, non-invasive detection of changes in PR expression with 18F-FFNP during an estradiol challenge may be an earlier indicator of the effectiveness of a specific hormone therapy." Findings from the study show that T47D human breast cancer ce...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news

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CONCLUSION: The tumour response to docetaxel was significantly influenced by the SNP C1236T of ABCB1 gene coding for the P-gp. However, when adjusted for other non-genetic factors, neither of the ABCB1 variants were found to be associated with tumour response to docetaxel-based NACT in LABC patients of South India. PMID: 30637776 [PubMed - indexed for MEDLINE]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Pharm Ther Source Type: research
Authors: Gonzalez-Villasana V, Rashed MH, Gonzalez-Cantú Y, Bayraktar R, Menchaca-Arredondo JL, Vazquez-Guillen JM, Rodriguez-Padilla C, Lopez-Berestein G, Resendez-Perez D Abstract miR-145, miR-155, and miR-382 have been proposed as noninvasive biomarkers to distinguish breast cancer patients from healthy individuals. However, it is unknown if these three miRNAs are secreted by exosomes. Thus, we hypothesized that miR-145, miR-155, and miR-382 in breast cancer patients are present in exosomes. We isolated exosomes from serum of breast cancer patients and healthy donors, then we characterized them according ...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
ConclusionThis case highlights the importance of using caution when combining radiation with the new targeted therapies. Until more data becomes available, physicians are recommended to exercise clinical judgment when deciding on whether to continue or discontinue a CDK4/6 inhibitor in a patient who may need radiation.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Rayfield Byrd knows when it’s time to wake up every morning. The 68-year-old Oakland, Cal., resident hears a voice from the living room offering a cheery good morning. Except Byrd lives alone. A little after 8 a.m. each day, a small yellow robot named Mabu asks Byrd how he’s doing. Byrd has Type 2 diabetes and congestive heart failure, and about three years ago, he had surgery to implant a microvalve in his heart to keep his blood flowing properly. To stay healthy, he takes four medications a day and needs to exercise regularly. To make sure his heart is still pumping effectively, his doctor needs to stay on to...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Artificial Intelligence Life Reinvented medicine Source Type: news
Taxol is a common chemotherapy (CTX) drug that is associated with the development of neuropathy. Paclitaxel-induced peripheral neuropathy (PIPN) is the dose limiting toxicity of this CTX drug. Paclitaxel exerts its therapeutic effect by binding to β-tubulin, which interferes with microtubule dynamics and results in microtubule stabilization, mitotic arrest, and apoptosis of cancer cells. However, microtubules are critical for axonal function and for the transport of essential organelles to distal nerve endings.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Acute postoperative pain is a predictable response and when left untreated can lead to chronic pain, prolonged rehabilitation, and other complications after breast surgery. Pectoral nerve block (PECSB) has been recently reported as an analgesic method for BCS. In recent literature, it is evident that PECSB significantly reduced intraoperative opioid usage, postoperative pain, PONV, and postoperative opioid requirements. Introduction of ultrasound in regional anesthesia practice influenced the practice and choice of blocks for any given surgery.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
We present a case of a 92-year-old female with history of hypertension, hyperlipidemia, macular degeneration, breast cancer and transient ischemic attach who presented to her primary care provider with sudden onset pain in the left thumb and forearm.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
The nuclear factor kappa beta (NF-kB) transcription factor complex is a regulatory element for genes involved in immune function and inflammation. Inflammatory processes are involved in the development and maintenance of symptom clusters. A polymorphism in subunit 2 of the NF-kB complex (NF-kB2) has been associated with symptom clusters in breast cancer patients. One of the most common symptoms experienced by breast cancer patients is pain. Little is known about the association between NF-kB2 and perception of pain in breast cancer patients.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Publication date: Available online 20 March 2019Source: SynergyAuthor(s): Ahmed Elwakeel, Hadeer Soudan, Ahmed Aldoksh, Manal Shalaby, Maha Eldemellawy, Doaa Ghareeb, Myriam Abouseif, Amira Fayad, Mostafa Hassan, Hesham SaeedAbstractTriple Negative Breast Cancer (TNBC) treatment is more challenging than other subtypes of breast malignancy and due to the lack of markers for the molecularly targeted therapies (ER, PR, and HER-2/Neu), the conventional chemotherapeutic agents are still the mainstay of the therapeutic protocols of its patients. Unfortunately, the initial good response to the chemotherapy eventually turns into a...
Source: Synergy - Category: Molecular Biology Source Type: research
Publication date: Available online 21 March 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Fátima Ferragut, Alejandro J. Cagnoni, Lucas L. Colombo, Clara Sánchez Terrero, Carlota Wolfenstein-Todel, María F. Troncoso, Silvia I. Vanzulli, Gabriel A. Rabinovich, Karina V. Mariño, María T. ElolaAbstractGalectin-8 (Gal-8), a ‘tandem-repeat’-type galectin, has been described as a modulator of cellular functions including adhesion, spreading, growth arrest, apoptosis, pathogen recognition, autophagy, and immunomodulation. We have previously shown ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
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