Development of pre-engraftment syndrome, but not acute graft-versus-host disease, reduces relapse rate of acute myeloid leukemia after single cord blood transplantation

Pre-engraftment syndrome (PES) is as a unique clinical manifestation with non-infectious fever and erythematous skin rash before neutrophil engraftment following cord blood transplantation (CBT) [1-11]. Although the incidence and severity of graft-versus-host disease (GVHD) after single CBT is usually lower compared with conventional adult donor hematopoietic cell transplantation (HCT) [12-15], the incidence of PES after CBT has been reported to be high, ranging from 20 to 78% [1-7].

Source: Biology of Blood and Marrow Transplantation - February 13, 2019 Category: Hematology Authors: Masamichi Isobe, Takaaki Konuma, Seiko Kato, Susumu Tanoue, Mai Mizusawa, Maki Oiwa-Monna, Satoshi Takahashi, Arinobu Tojo Source Type: research