Experimental 'nano-painkiller' is more effective and less addictive than morphine

Researchers at the University of Delaware and in France re-engineered naturally occurring compounds to treat pain with longer lasting effects than morphine but minimal addiction risk.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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The National Institutes of Health (NIH) would receive $34.4 billion in FY 2020, roughly $4.7 billion or 13 percent below the levels enacted by Congress for FY 2019, according to the President’s Budget released on March 11. The budget for NIH includes $492 million in funding made available through the 21st Century Cures Act and $150 million in mandatory funding. The leading biomedical research agency in the world would receive budget cuts across the board. All NIH centers are slated for budget reductions: National Cancer Institute: -8.7 percent National Heart, Lung, and Blood Institute: -14 percent National Inst...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
Suffering is a shared human experience that can be viewed integral part of life. Our suffering can range from mild to severe and can take the form of physical or mental and emotional pain. Whatever the form of our discomfort, we can agree that “suffering of the mind” is one of the biggest concerns of our time. The severity of mental health issues is on the rise, particularly the number of individuals experiencing depression. According to the World Health Organization (2017) over 300 million people are estimated to suffer from depression, equivalent to 4.4% of the world’s population. The Causes...
Source: Psych Central - Category: Psychiatry Authors: Tags: Depression Habits Mindfulness Self-Help Source Type: news
The United States uses a third of the world's opioids but a fifth of Americans still say they suffer from chronic pain. The only demonstrable effect of two decades of widespread prescription of opioids has been catastrophic harm. With more than 47,000 Americans dying of opioid overdoses in 2017 and hundreds of thousandsmore addicted to them, it was recently reported that, for the first time, Americans were more likely to die of opioids than of car accidents.This has forced many to take a step back and ponder the very nature of pain, to understand how best to alleviate it.The ancient Greeks considered pain a passion &md...
Source: Psychology of Pain - Category: Anesthesiology Source Type: blogs
Publication date: Available online 16 March 2019Source: PeptidesAuthor(s): Lori N. Eidson, Anne Z. MurphyAbstractEach year, over 50 million Americans suffer from persistent pain, including debilitating headaches, joint pain, and severe back pain. Although morphine is amongst the most effective analgesics available for the management of severe pain, prolonged morphine treatment results in decreased analgesic efficacy (i.e., tolerance). Despite significant headway in the field, the mechanisms underlying the development of morphine tolerance are not well understood. The midbrain ventrolateral periaqueductal gray (vlPAG) is a ...
Source: Peptides - Category: Biochemistry Source Type: research
Authors: Pergolizzi JV, Lequang JA, Passik S, Coluzzi F Abstract Healthcare professionals and organizations increasingly face the conundrum of treating patients with active substance use disorder, a history of personal or familial substance use disorder, or those at elevated risk for substance abuse. Such patients need compassionate care when facing painful conditions; in fact, denying them pain control makes it likely that they will seek out ways to self- medicate with illicit drugs. Yet it remains unclear how to safely and effectively treat patients in these challenging situations. The authors have formulated ten...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
The evolution of VR hardware and software What’s the best VR will do VR, AR, MR or spatial computing? The potential of interactive immersive reality Challenges and obstacles in adoption How will immersive reality transform everyday life? What was the last time you met sci-fi? The dark side of technology Imagine that a doctor sits down in Starbucks, places some glasses on his head, instantly invokes five screens and starts doing his diagnostic work. Robert Scoble, virtual reality expert, and tech evangelist believes that will be possible in the coming years – sooner than we might think. He told us why his wi...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Great Thinkers AR augmented reality future HoloLens Innovation MR Oculus technology virtual virtual reality VR XR Source Type: blogs
ConclusionsCollectively, these electrophysiological and neurochemical experiments suggest that the rewarding properties of pregabalin result from a different mode of action than that observed with cocaine. Further experiments are warranted to determine whether such undesirable effects can be potentiated under pathological conditions such as neuropathic pain, mood disorders, or addiction and to identify the key neurotransmitter system involved.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Deaths from opioid overdoses have increased dramatically over the last decade. In 2017, the latest year for which the U.S. government has statistics on the trend, more than 47,000 Americans died of opioid overdoses. One major factor contributing to the rising number of people who get addicted to opioids and die from overdoses is the increasing number of prescriptions written by doctors to treat pain. Overdose deaths related to such prescriptions increased five times from 1999 to 2017. But according to the latest study looking at opioid prescribing patterns, published in the New England Journal of Medicine, recent efforts t...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Drugs Source Type: news
No one likes to feel sad. Sorrow can be hard to contend with and it can seem like it will never go away. Many of us try hard to push those emotions down and ignore them. But ignoring feelings doesn’t make them go away, and trying to do so can often lead to bigger problems down the road. The truth is that you can’t really push emotions out of the way and get rid of them. It simply doesn’t work that way. Trying to do so is generally a matter of distraction and avoidance. And once the distractions stop working, those feelings will still be there needing to be dealt with. Even so, there are many who would st...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Self-Help Emotional Expression Sadness Source Type: blogs
Notice NOT-NS-19-043 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
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