Evaluation of sperm telomere length in infertile men with failed/low fertilization after intracytoplasmic sperm injection

ConclusionsFailed/low fertilization rates could be related to oxidative stress resulting in short telomere length, and also increased sperm chromatin damage and lipid peroxidation. From literature sources, shortened telomere length may lead to detachment of chromosomes from the nuclear membrane, the consequences of which are defects in the process of spermatogenesis, pronuclei formation, and delayed or arrested cell cycle post-ICSI.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research