The BeWo cell line derived from a human placental choriocarcinoma is permissive for respiratory syncytial virus infection

In this study, we examined the capacity of RSV to infect a human trophoblast model, the BeWo cell line. Our results suggest that BeWo cells are susceptible to RSV infection since they allow RNA viral replication, viral protein translation, leading to the production of infectious RSV particles. In this report, we demonstrate that a human placenta model system, consisting of BeWo cells, is permissive to RSV infection. Thus, the BeWo cell line may represent a useful model for studies that aim to characterize the events of a possible RSV infection at the human maternal –fetal interface.
Source: Virus Genes - Category: Genetics & Stem Cells Source Type: research