Evaluation of novel imaging devices for nanoparticle-mediated fluorescence-guided lung tumor therapy.

CONCLUSIONS: These results support the potential for clinical translation of this novel platform to impact non-surgical and minimally-invasive treatment options for early stage peripheral lung cancer. PMID: 30742818 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research

Related Links:

In this study, we showed that LKB1 overexpression could phosphorylate YAP and promoted its nuclear rejection. Silencing LKB1 could dephosphorylate YAP and promoted its entry into the nucleus. Here, we found that LKB1 inhibited the mRNA expression and the amplification of hTERC. YAP further up-regulated hTERC at mRNA and gene amplification levels. Therefore, we suggest that LKB1 may inhibit the expression and amplification of hTERC through the axis of LKB1-pYAP(YAP)-hTERC.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
ConclusionSBRT with a moderate dose in 4 –6 fractions is effective and tolerable for patients with advanced stage UC‐NSCLC. However, caution should be taken considering possible treatment‐related death. Further studies are warranted.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionHypofractionated PBT may be a very safe and effective treatment option for centrally located early lung cancer.
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Radiation Oncology —Original Article Source Type: research
This study enrolled 89 lung adenocarcinoma patients with an average age of 60.1 ± 8.1 years (range, 36-78 years; male: female = 24: 65). The proportion of mixed GGN (mGGNs), polygonal/irregular shape, lobulated/spiculated edge, and dilated/distorted/cut-off bronchial sign were higher in IAC than in pre-invasive-MIA GGNs, as well as the attenuation value of the ground-glass opacity (GGO) component (CTGGO), the difference of CTGGO and normal lung parenchyma adjacent to GGO (CTGGO-LP), maximum standard uptake value (SUVmax), and SUV index (tumor SUVmax/liver SUVmean) (P range: 0.001-0.022) (Figure 1 and Figure 2). Univ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer Posters Source Type: research
Authors: Gołota J, Osowiecka K, Orłowski T Abstract Introduction: Primary pulmonary sarcomas (PPS) are rare types of non-epithelial malignant tumors of the lungs (0.013-1.1% of all malignant lung tumors). The PPS can originate from mesenchymal elements of the bronchial wall, vessels or pulmonary stroma. Since the introduction of immunohistochemical and molecular diagnosis, a significant improvement in description and classification of sarcomas has been achieved. Nonetheless, sarcomas still remain a diagnostic and clinical problem. Aim: To estimate factors which could have an influence on the overall survival (OS)...
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
A 68-year-old female never-smoker received a diagnosis of stage-IV lung adenocarcinoma (cT2N3M1b) in October 2014. Testing of oncodriver mutational status at time of diagnosis in the initial bronchial biopsy identified an EGFRdel19 mutation (c.2235_2249del,p.Glu746_Ala750del). Four cycles of pemetrexed/cisplatin/bevacizumab were administered as first-line therapy. At progression, the patient was treated with afatinib, an oral tyrosine kinase inhibitor (TKI) sensitizing EGFR mutations (Fig. 1). After a first phase of partial clinical response according to the RECIST (Response Evaluation Criteria in Solid Tumors) V.1.1 crite...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, we further examined this process in vivo by using heterozygous PARG knockout mice (PARG+/−). Wild-type and PARG+/− mice were individually treated with 0 or 10 μg/m3 BaP for 90 or 180 days by dynamic inhalation exposure. Pathological analysis of lung tissues showed that, with extended exposure time, carcinogenesis and injury in the lungs of WT mice was progressively worse; however, the injury was minimal and carcinogenesis was not detected in the lungs of PARG+/− mice. These results indicate that PARG gene silencing protects mice against lung cancer induced by BaP inhalation exposure. Fur...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Acetylcholine receptors (AChRs), including nicotinic acetylcholine receptors (nAChRs) and muscarinic acetylcholine receptors (mAChRs), are highly expressed in bronchial epithelial cells. We used The Cancer Genome Atlas (TCGA) data set to evaluate the expression pattern and prognostic value of the AChR gene family in non-small cell lung cancer (NSCLC). The mined data was validated by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC). The survival analysis of TCGA data set showed that only CHRNA7 in the AChR gene family affected prognosis in both lung adenocarcinoma and lung squamous...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Abstract A blood-based approach such as circulating tumor DNA remains challenging in diagnosis for early-stage disease. Bronchial washing (BW) is a minimally invasive procedure that yields fluids that may contain tumor DNA. Therefore, we prospectively enrolled 12 patients with early-stage non-small cell lung cancer without endoscopically visible tumors. Somatic mutations were analyzed using ultra-deep next-generation sequencing in 48 paired specimens (primary tumor tissue, normal tissue, BW supernatant, and BW precipitate). In primary tumors, 130 missense mutations/indels (5-16 per patient) and 20 driver mutations...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
More News: Bronchial Tumour | Bronchoscopy | Cancer | Cancer & Oncology | Cardiovascular & Thoracic Surgery | Lung Cancer | Nanotechnology | PET Scan | Science | Study | Transplants