Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice

Conclusions: Our data demonstrate that GW3965 exerts a cardioprotective effect against DCM by (at least in part) attenuating insulin resistance, modulating Akt and MAP kinases pathways, and reducing oxidative/nitrative stress and inflammatory response. These findings strongly suggest that LXR agonist may have therapeutic potential in treating DCM.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research