Proinflammatory CD20+ T cells in the Pathogenesis of MS Proinflammatory CD20+ T cells in the Pathogenesis of MS

This study aimed to elucidate the role of CD20+ T cells in the pathogenesis of MS. Might depletion of CD20+ T cells contribute to the positive treatment effect of anti-CD20 antibody therapies?Brain
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

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We report a patient with Crohn’s disease who was diagnosed with signet-ring cell carcinoma in the setting of a Crohn’s flare. Diagnosis was made with endoscopy. Treatment included laparoscopic-assisted right hemicolectomy with ileostomy with subsequent chemotherapy as an outpatient .Case Rep Gastroenterol 2019;13:85 –88
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionIn conclusion, GDM and macrosomia, but not PCOS, are significant risk factors for T2DM in our Lebanese cohort. Our results, reported for the first time in the Middle East, present insights into risk factors management and disease prevention.
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research
This study aimed to investigate the combined effect of oral citicoline and DHA treatment on improvement of cognitive deficits following cerebral ischemia using a 20-min bilateral common carotid artery occlusion (BCCAO) mouse model. BCCAO ischemic mice were treated for a total of 11 days with a combination of citicoline (40 mg/kg body weight/day) and DHA (300 mg/kg body weight/day) or each alone. Combined citicoline and DHA synergistically and significantly improved learning and memory ability of ischemic mice compared with either alone. Further, citicoline and DHA treatment significantly prevented neuronal cell death, and ...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 February 2019Source: Journal of Ginseng ResearchAuthor(s): Mee Youn Lee, Han Sol Seo, Digar Singh, Sang Jun Lee, Choong Hwan LeeAbstractBackgroundGinseng berries (GBs) show temporal metabolic variations among different maturation stages, determining their organoleptic and functional properties.MethodsWe analyzed metabolic variations concomitant to five different maturation stages of GBs including immature green (IG), mature green (MG), partially red (PR), fully red (FR) and over-mature red (OR) using mass spectrometry (MS) based metabolomic profiling and multivariate analyses.ResultsTh...
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
ConclusionInfection by the weakly aggressive I. robusta led to the upregulation of ginsenoside production and biosynthesis, probably because only a low level of ROS was induced. In contrast, the more aggressive I. mors-panacis suppressed ginsenoside biosynthesis, probably because of higher ROS levels and subsequent induction of programmed cell death pathways. Furthermore, I. mors-panacis may have increased its virulence by resisting the cytotoxicity of ROS.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
Individuals who perform interval training, especially sprint interval training, appear to lose more weight than those who do moderate-intensity continuous exercise, suggests a meta-analysis.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
(Reuters Health) - That younger siblings are most likely to experience bullying within a family, and the eldest is most likely to do the bullying may not come as a surprise to those who grew up in large broods.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Most American teenagers say they view anxiety and depression as a major problem in the communities where they live, a Pew study released Wednesday indicates.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Sacituzumab, is an antibody that zeroes in on cancer cells. Like a homing missile, it delivers a 'warhead' in the form of a potent chemotherapy drug.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Sinonasal undifferentiated carcinoma (SNUC) is a rare, poorly differentiated and aggressive malignancy of the nasal cavity and paranasal sinuses first reported by Frierson et al. in 1986 with less than 300 known cases reported since then. Due to the rarity and aggressive nature of the disease, there is a lack of consensus regarding optimal management in these patients. Treatment decisions have mostly been guided by a small number of cases series and can vary widely between institutions. In this unique case presentation, we review a case of sinonasal undifferentiated carcinoma in a young Hispanic male reviewing the literatu...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
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