Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users

Anabolic androgenic steroids (AAS) have been associated with coronary artery disease (CAD). AAS abuse leads to a remarkable decrease in high-density lipoprotein (HDL) plasma concentration, which could be a key factor in the atherosclerotic process. Moreover, not only the concentration of HDL, but also its functionality, plays a pivotal role in CAD. We tested the functionality of HDL by cholesterol efflux and antioxidant capacity. We also evaluated the prevalence of CAD in AAS users.

Source: Atherosclerosis - February 12, 2019 Category: Cardiology Authors: Francis Ribeiro de Souza, Marcelo Rodrigues dos Santos, Rafael Armani Porello, Guilherme Wesley Peixoto da Fonseca, Ana Luiza Carrari Sayegh, Tha ís Pinheiro Lima, Fabiana Dias Ferreira, Tiago Franco de Oliveira, Maurício Yonamine, Liliam Takayama, Rosa Source Type: research