Vanillin ameliorates changes in HIF-1 α expression and neuronal apoptosis in a rat model of spinal cord injury.

Vanillin ameliorates changes in HIF-1α expression and neuronal apoptosis in a rat model of spinal cord injury. Restor Neurol Neurosci. 2019 Feb 04;: Authors: Chen H, Zheng J, Ma J Abstract BACKGROUND: In the search for treating neurological dysfunctions after spinal cord injury (SCI), methods of neuroprotection are of interest to intervene with the caspase pathway. OBJECTIVE: To evaluate the neuroprotective effects of vanillin in a rat model of spinal cord injury (SCI). METHODS: Rats were randomly assigned to one of three groups: a sham-operated group, and two groups where SCI was produced by ischemia/reperfusion which received either saline or vanillin (286 mg/kg, intraperitoneal [i.p.] 30 min prior to surgery). Neurological function was estimated by the Tarlov scale at 1, 12, and 24 h after surgery. Additionally, we estimated the levels of oxidative stress, inflammatory cytokines, and mitochondrial proteins in the homogenates of spinal tissues and terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) and immunohistochemical assays of spinal tissues. RESULTS: Motor dysfunction was found to be significantly improved in the vanillin treated group compared to SCI rats. This was accompanied by altered levels of oxidative stress, inflammatory cytokines, and expressions of mitochondrial proteins in the SCI rats which were ameliorated by the vanillin treatment. Vanillin also significantly reduced the number of TUNEL-...
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

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Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Brief Reports Source Type: research
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Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Case Report Source Type: research
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Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
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Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research
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