Highmark reaches settlement with specialty pharmacy

Highmark and Highmark Benefits Group have settled a federal lawsuit filed by a Florida-based speciality pharmacy that claimed the insurer denied payments for specialty pharmacy medications for people suffering from the blood disease hemophilia. The settlement announced Tuesday afternoon between Highmark and BioMatrix ends the lawsuit. Details weren’t released other than to say that Highmark and BioMatrix, a Weston, Florida, company that manufacturers specialty medications to treat hemophilia,…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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This study aimed to monitor the daily PA and analyse its evolution over time in a cohort of PWH using a commercial activity tracker. In addition, this work analyses the relationship between PA levels, demographics, and joint health status, as well as the acceptance and adherence to the activity tracker. Twenty-six PWH were asked to wear a Fitbit Charge HR for 13 weeks. According to the steps/day in the first week, data were divided into two groups: Active Group (AG; ≥10,000 steps/day) and Non-Active Group (NAG; <10,000 steps/day). Correlations between PA and patient characteristics were studied using the Pear...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Condition:   Haemophilia Interventions:   Other: Progressive balance training;   Other: Normal daily activities Sponsor:   University of Valencia Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Rodriguez-Merchan EC Abstract Introduction: It is paramount that physicians treating people with hemophilia (PWH) assess their degree of satisfaction. Areas covered: The most important predictors of the difficulties of treatment satisfaction are the perceived barriers, the level of skills related to self-treatment, the degree of severity of hemophilia and the affective status. The use of an electronic diary improves the adherence of PWH with respect to the registration of the mandatory information of their treatment. Asymptomatic HIV-positive PWH are more dissatisfied than HIV-negative PWH due to the effec...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
ConclusionsHemophilia A with high-titer inhibitors is a disease that generates significant pressure on the Colombian health system, mainly linked to the cost of factors and bypassing agents.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
The exon recognition and removal of introns (splicing) from pre-mRNA is a crucial step in the gene expression flow. The process is very complex and therefore susceptible to derangements. Not surprisingly, a significant and still underestimated proportion of disease-causing mutations affects splicing, with those occurring at the 5’ splice site (5’ss) being the most severe ones. This led to the development of a correction approach based on variants of the spliceosomal U1snRNA, which has been proven on splicing mutations in several cellular and mouse models of human disease. Since the alternative splicing mechanis...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
We present a case of a 68-year-old Hispanic female with a history of factor VII deficiency who presented with shortness of breath, chest pain, and palpitations and was found to have pulmonary embolism. Our patient did not have any of the above-mentioned thrombotic risk factors. Our case and review of the literature show that factor VII deficiency does not provide protection against thrombosis. PMID: 31590173 [PubMed - as supplied by publisher]
Source: Acta Haematologica - Category: Hematology Authors: Tags: Acta Haematol Source Type: research
Series Type : Expression profiling by high throughput sequencing ; Expression profiling by arrayOrganism : Mus musculus ; mouse gut metagenomeThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Expression profiling by array Mus musculus mouse gut metagenome Source Type: research
Contributors : Julie Tarrant ; Matthew CormierSeries Type : Expression profiling by arrayOrganism : Mus musculusThe development of neutralizing FVIII antibodies is the most serious complication of hemophilia A treatment. The currently known patient- and treatment-related risk factors for inhibitor development do not accurately predict this adverse event in all patients. The composition of the gut microbiota has been shown to influence immune mediated diseases at distant anatomical sites (e.g. lungs, brain and joints). We demonstrate that a disrupted gut microbiome can be created in a mouse model of hemophilia A using a bro...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Contributors : Julie Tarrant ; Matthew CormierSeries Type : Expression profiling by high throughput sequencingOrganism : mouse gut metagenomeThe development of neutralizing FVIII antibodies is the most serious complication of hemophilia A treatment. The currently known patient- and treatment-related risk factors for inhibitor development do not accurately predict this adverse event in all patients. The composition of the gut microbiota has been shown to influence immune mediated diseases at distant anatomical sites (e.g. lungs, brain and joints). We demonstrate that a disrupted gut microbiome can be created in a mouse mode...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing mouse gut metagenome Source Type: research
CONCLUSIONS: Exercises performed both with elastic bands and with machines at moderate intensity are safe, feasible, and efficient in people with severe hemophilia, providing comparable activity levels in the agonist muscles. PMID: 31584672 [PubMed - as supplied by publisher]
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: Phys Ther Source Type: research
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