Effects of aflatoxin B1 on the cell cycle distribution of splenocytes in chickens.

In conclusion, dietary AFB1 could induce cell cycle blockage at G0G1 phase and impair the immune function of the spleen. Cyclin D1/CDK6 complex, which inhibits the activin/nodal signaling pathway, might play a significant role in the cell cycle arrest induced by AFB1. PMID: 30739993 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/30739993?dopt=Abstract

Source: Journal of Toxicologic Pathology - February 13, 2019 Category: Toxicology Tags: J Toxicol Pathol Source Type: research