Pretreatment assessment of hematologic and inflammatory markers in adenoid cystic carcinoma: neutrophil/lymphocyte ratio is associated with multiple recurrences

ConclusionsThis study showed that the NLR may serve as a useful prognosticator for a high risk of multiple recurrences in patients with ACC.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research

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Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractObjectivesThe aim of this study was to investigate the predictive value of the biomarkers FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas.Material and methodsImmunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall survival, and disease-specific survival were examined.ResultsExpression of FHIT (quick score 98.7 vs. 206.4) and p27 (QS 187.3 vs. 244.8) was significantly lower in carcinomas compared to non-tumor control tissue. Loss of FHIT frequently occurred in ACC (55.2%), SDC (68.2%),...
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
ConclusionsThis study shows, that NLR may serve as a useful prognosticator for a high risk of multiple recurrences in ACC patients.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Adenoid cystic carcinoma (ACC) is a rare entity of salivary gland cancer. Inflammatory and hematologic markers and their prognostic and predictive value have been intensively studied in several cancer entities. The aim of this study was to investigate the role of such markers in patients with ACC.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Oral and Maxillofacial SurgerySe Source Type: research
The androgen receptor (AR) is a nuclear steroid receptor that binds to testosterone and dihydrotestosterone and regulates the transcription of genes leading to cell growth, differentiation and survival. AR serves as an important oncogenic signal in prostate cancers and apocrine breast cancers. Salivary duct carcinoma (SDC) is a rare subtype of head and neck cancer that is defined by an apocrine phenotype, with AR positivity by immunohistochemistry (IHC) in up to 98% of cases [1]. A recent clinical trial with leuprorelin acetate and bicalutamide has shown promising activity with an overall response rate of 42% in AR-positiv...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Letter to the editor Source Type: research
Salivary gland cancers comprise a wide histological spectrum with more than twenty different subtypes [1]. In 2010, a new entity of salivary gland cancer was described by Sk álová et al., characterized by the presence of the ETV6-NTRK3 fusion gene [2]. The histopathological appearance resembles secretory carcinoma of the breast, and both tumors share the ETV6-NTRK3 fusion gene, hence the proposed name was mammary analogue secretory carcinoma (MASC). In the updated 201 7 WHO classification, MASC is acknowledged and referred to as ‘secretory carcinoma’, to standardize nomenclature amongst different organ sites [1].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Salivary gland cancer is a rare disease that accounts for approximately 5% of all head and neck cancers and 0.3% of all human cancers [1 –3]. Salivary gland carcinoma arises in various regions of the major and minor salivary glands, presenting at least 24 different histological subtypes with different clinical features of metastasis and recurrence [4,5]. Distant metastases are relatively common in salivary gland carcinoma [6], and may be present at initial presentation or may emerge during the post-treatment period.
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsIn studied salivary gland cancers no PCR based prove mutations of BRAF V600 were detected. Further molecular analyses are necessary, in order to rapid molecular arrays for the identification of specific mutations, optimal for individualized targeted therapies.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - Category: Pathology Authors: Tags: Original Article Source Type: research
Conclusions ADT should be considered as a therapeutic option for unresectable advanced SDC.
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
Salivary gland cancers (SGCs) are uncommon diseases accounting for only 2 –6.5% of all head and neck cancers, and are characterized by considerable variability in their biology and natural history [1]. Mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and adenocarcinoma are the most frequent diagnoses, representing> 75% of all SGCs, although their frequency varies according to the site of origin (major vs minor salivary glands) [2]. Prognosis among SGCs differs according to histology and grading: non-ACC and high-grade tumors are associated with a poorer prognosis compared with low-grade tumors [3 –5].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
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