Generating Kidney from Stem Cells.

Generating Kidney from Stem Cells. Annu Rev Physiol. 2019 Feb 10;81:335-357 Authors: Little MH, Hale LJ, Howden SE, Kumar SV Abstract Human kidney tissue can now be generated via the directed differentiation of human pluripotent stem cells. This advance is anticipated to facilitate the modeling of human kidney diseases, provide platforms for nephrotoxicity screening, enable cellular therapy, and potentially generate tissue for renal replacement. All such applications will rely upon the accuracy and reliability of the model and the capacity for stem cell-derived kidney tissue to recapitulate both normal and diseased states. In this review, we discuss the models available, how well they recapitulate the human kidney, and how far we are from application of these cells for use in cellular therapies. PMID: 30742789 [PubMed - in process]
Source: Annual Review of Physiology - Category: Physiology Authors: Tags: Annu Rev Physiol Source Type: research