Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy ‐induced peripheral neuropathy: A mediation effect analysis

This is a rare study to investigate the relationship among daily activity, mood, and quality of life (QoL) in colorectal cancer patients with chemotherapy ‐induced peripheral neuropathy (CIPN), by using the mediation effect analysis. According to the results, the mediation effect of mood between daily activities and QoL should be further emphasized for colorectal cancer patients with CIPN. AbstractChemotherapy ‐induced peripheral neuropathy (CIPN) with restriction of daily activity (RDA) was common consequence of oxaliplatin‐based chemotherapy in colorectal cancer patients. CIPN with RDA and negative mood may impact the quality of life (QoL). However, the relationships among RDA, mood, and QoL remain unclear. This was a cross‐sectional relative study in which four instruments were used: the Neuropathic Pain Symptom Inventory was used to measure the severity of CIPN; the Screening of Activity Limitation and Safety Awareness scale was used to evaluate RDA; the Profile of Mood States Short Form w as used to assess negative mood; and the Functional Assessment Cancer Center Therapy‐Colorectal scale version 4 was used to evaluate QoL. Relationships among the variables were analyzed by bivariate correlation, hierarchical multiple linear regression, and Baron and Kenny's mediation testing. One hundred three colorectal adenocarcinoma patients with CIPN after receiving oxaliplatin‐based chemotherapy were enrolled. Patients had mild‐to‐moderate CIPN and mild RDA. Signifi...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
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Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
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Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
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Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
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 DOI: 10.3779/j.issn.1009-3419.2020.01.06
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
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Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
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 DOI: 10.3779/j.issn.1009-3419.2020.01.08
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
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