Aquaporin 5 –1364A/C Promoter Polymorphism Is Associated with Pulmonary Inflammation and Survival in Acute Respiratory Distress Syndrome

Editor ’s PerspectiveWhat We Already Know about This TopicAcute respiratory distress syndrome is defined according to clinical criteria, but lack of precise characterization may contribute to negative trials and impede personalized care. Polymorphisms of aquaporin-5, a key mediator of inflammation, may impact outcome.What This Article Tells Us That Is NewIn acute respiratory distress syndrome attributable to bacterial pneumonia, the C-allele of the aquaporin-5 –1364A/C promoter polymorphism is associated with less pulmonary inflammation and greater survival. This may improve characterization of acute respiratory distress syndrome and ultimately facilitate individualized care.Background The aquaporin-5 (AQP5) –1364A/C promoter single-nucleotide polymorphism is associated with an alteredAQP5 expression and mortality in sepsis. BecauseAQP5 expression alters neutrophil cell migration, it could affect pulmonary inflammation and survival in bacterially evoked acute respiratory distress syndrome. Accordingly, the authors tested the hypotheses that the AC/CC genotype in patients with bacterially evoked pneumonia resulting in acute respiratory distress syndrome is associated with (1) attenuated pulmonary inflammation and (2) higher 30-day survival.Methods In this prospective, observational study, bronchoalveolar lavage and blood sampling were performed within 24  h of intensive care unit admission. In 136 Caucasian patients with bacterially evoked acute respir...
Source: Anesthesiology - Category: Anesthesiology Source Type: research

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