Methylation of HIF3A promoter CpG islands contributes to insulin resistance in gestational diabetes mellitus

ConclusionOur findings demonstrate that the expression level ofHIF3A, but notHIF1A orHIF2A, is downregulated in GDM patients. The methylation status ofHIF3A promoter region is highly correlated with GDM, which could be a novel therapeutic target for GDM treatment.

Source: Molecular Genetics & Genomic Medicine - February 11, 2019 Category: Genetics & Stem Cells Authors: Yinghong Zhang, Yangyang Chen, Hongmei Qu, Yuanli Wang Tags: ORIGINAL ARTICLE Source Type: research