Cardiac Function After Radiotherapy for Breast Cancer

The relationship between individual cardiac dose distributions and systolic and diastolic dysfunction is unclear. We conducted a cross-sectional study consisting of 109 breast cancer survivors treated with post-operative radiotherapy (RT). The endpoint was systolic and diastolic cardiac function, assessed by echocardiography. Although no relation between RT dose parameters and left ventricle ejection fraction was found, an association between individual RT dose and global longitudinal systolic strain of the left ventricle was determined.

Source: International Journal of Radiation Oncology * Biology * Physics - February 11, 2019 Category: Radiology Authors: Veerle A.B. van den Bogaard, Peter van Luijk, Yoran M. Hummel, Peter van der Meer, E. Schuit, Liselotte M. Boerman, Saskia W.M.C. Maass, Jan.F. Nauta, Lars C. Steggink, Jourik A. Gietema, Geertruida H. de Bock, Annette J. Berendsen, Wilma G.J.M. Smit, Nan Tags: Clinical Investigation Source Type: research