Corneal Substructure Dosimetry Predicts Corneal Toxicity in Patients with Uveal Melanoma Treated with Proton Beam Therapy

In patients with uveal melanoma treated with proton beam therapy, we examine the relationships of tumor-related factors and corneal dose-volume parameters with incidence of grade 2+ intervention-requiring corneal toxicity. Patients with anterior uveal melanomas experience a high rate of GR2+ corneal toxicity due to increased corneal dose. Anterior location and corneal DVH parameters independently predict toxicity risk. We propose dosimetric constraints to facilitate treatment planning and toxicity mitigation.

Source: International Journal of Radiation Oncology * Biology * Physics - February 11, 2019 Category: Radiology Authors: Howard J. Lee, Andrew Stacey, Todd R. Klesert, Craig Wells, Alison Skalet, Charles Bloch, Angela Fung, Stephen R. Bowen, Tony P. Wong, Dean Shibata, Lia M. Halasz, Ramesh Rengan Tags: Clinical Investigation Source Type: research