More men with low-risk prostate cancer are forgoing treatment, study finds

More men with low-risk prostate cancer are forgoing treatment to instead watch and wait to see whether their cancer progresses -- and experts say that's a good thing.
Source: - Health - Category: Consumer Health News Source Type: news

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Authors: Rae C, Mairs RJ Abstract Although radiotherapy is often used to treat localized disease and for palliative care in prostate cancer patients, novel methods are required to improve the sensitivity of aggressive disease to ionizing radiation. AMP-activated protein kinase (AMPK) is an energy sensor which regulates proliferation, aggressiveness and survival of cancer cells. We assessed the ability of the AMPK activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) to sensitize prostate cancer cells to radiation. Prostate cancer cell lines LNCaP and PC3 were treated with X-rays and AICAR then ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Trujillo-Cáceres SJ, Torres-Sánchez L, Burguete-García AI, Orbe Orihuela YC, Vázquez-Salas RA, Álvarez-Topete E, Gómez R Abstract Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. MSMB gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Herein, socio-...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Wang Y, Schafler ED, Thomas PA, Ha S, David G, Adney E, Garabedian MJ, Lee P, Logan SK Abstract Ubiquitously-expressed, prefoldin-like chaperone (UXT) also called Androgen Receptor Trapped clone-27 (ART-27) is widely expressed in human tissues. Our previous studies showed that UXT regulates transcription repression including androgen receptor (AR) signaling in prostate cancer. Here we analyzed a tissue microarray consisting of normal prostate, benign prostatic hyperplasia, high grade prostatic intraepithelial neoplasia (HGPIN) and primary prostate cancer cases for UXT protein expression. We found that HGPI...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study lays the groundwork for future structure-based development of more potent and selective small molecule inhibitors of hnRNP A1–RNA interactions aimed at altering the production of cancer-specific alternative splice isoforms.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
CONCLUSIONS: Ga-PSMA PET/CT shows promise as a sole whole-body imaging modality for assessing the presence of soft tissue and bone metastases in the setting of prostate cancer. PMID: 30772960 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
ConclusionMost common site of colorectal carcinoma left colon, which present in 61.97%. There is increase in new cases detection of colorectal carcinoma from 2013 to 2016. Advanced stages cancer were most common stages description as IIIA, IIIB, IIIC and IV in 12.67%, 16.90%, 19.72% and 15.49%. The common histopathological pattern is differentiated adenocarcinoma as 53.52%.ResumoIntroduçãoO carcinoma colorretal é o câncer mais comum do trato gastrointestinal. É o terceiro tipo de câncer mais observado no sexo masculino mundialmente, atrás dos cânceres de pulmão e ...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Conclusions The data suggested that Sinomenine could suppress cell proliferation, migration, invasion, and promote apoptosis of prostate cancer cells through regulation of miR-23a. These findings might provide a possible strategy for the clinical treatment of prostate cancer.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsMulticellular 3D spheroids can be generated from patient-derived RP tissue samples and serve as an innovative in vitro model of organ-confined PCa.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Prostate Cancer;   Androgen Deprivation Therapy Intervention:   Drug: HIFU hemi-ablation combined with ADT. Sponsors:   Institut Mutualiste Montsouris;   University of Turin, Italy Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Enzalutamide added to androgen deprivation therapy (ADT) improved outcomes in metastatic hormone-sensitive prostate cancer (mHSPC) as compared with ADT alone.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Urology News Source Type: news
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