Dementia Beyond Pathology: What People Diagnosed Can Teach Us About Our Shared Humanity

AbstractIn this article, I explore how methods of investigation can allow us either to appreciate the intact cognitive and social abilities of people with Alzheimer ’s disease or unwittingly obscure those same abilities. Specifically, I shall assert that (1) the biomedical- quantitative approach, while being generally appropriate for drug efficacy studies, does not allow us to appreciate the many significant strengths possessed by people diagnosed with dement ia, (2) qualitative/narrative approaches do so admirably, and (3) understanding the cognitive and social strengths of people diagnosed is of paramount importance for developing optimal care giving approaches and reveals strikingly the shared humanity of those diagnosed with dementia and those deemed healthy.
Source: Journal of Bioethical Inquiry - Category: Medical Ethics Source Type: research

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Traumatic brain injury (TBI) and Alzheimer's disease (AD) bear a complex relationship, potentially increasing risk of one another reciprocally. However, recent evidence suggests post-TBI dementia exists as a distinct neurodegenerative syndrome, confounding...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
(Alzheimer's Association) The Alzheimer's Association and University College London (UCL) are partnering to study brain aging and dementia in 500 individuals whose health and health-related behaviors have been documented since birth. A $7 million grant from the Alzheimer's Association will allow researchers to more accurately detect the influence of both genetics and behaviors on dementia risk across the life course in this unique population.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This study was designed to test the hypothesis that nondependent alcohol drinking exacerbates the onset and magnitude of AD-like neural and behavioral pathology. We first evaluated the impact of voluntary 24-h, two-bottle choice home-cage alcohol drinking on the prefrontal cortex and amygdala neuroproteome in C57BL/6J mice and found a striking association between alcohol drinking and AD-like pathology. Bioinformatics identified the AD-associated proteins MAPT (Tau), amyloid beta precursor protein (APP), and presenilin-1 (PSEN-1) as the main modulators of alcohol-sensitive protein networks that included AD-related proteins ...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
This article challenges Mills ’ argument. Not only can children be duty-bound to visit parents who have lost the ability to recognise them, I argue that many children do in fact have such duties. As I show, these duties are grounded in any special interests that their parents have in their company; the fact that visiting their parents might allow them to comply with generic duties of sociability; and/or the fact that such visits allow them to express any gratitude that they owe their parents.
Source: Medicine, Health Care and Philosophy - Category: Medical Ethics Source Type: research
(Natural News) Dementia is a collective term for diseases like Alzheimer’s that affect a person’s brain and his ability to think and remember. With over 50 million people having dementia worldwide and 10 million new cases being diagnosed annually, it is one of the fastest growing health conditions globally. Common signs of early-stage dementia are impaired cognitive...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
A study of 35 people with and without Alzheimer's disease found that hyperspectral imaging of the retina could aid early diagnosis of the disease.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
CONCLUSIONS: Brexpiprazole 2 mg/day has the potential to be efficacious, safe, and well tolerated in the treatment of AAD. PMID: 31708380 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
(Alzheimer's Association) 5-year grant aimed at identifying evidence-based strategies to enhance care and support for individuals with dementia and their care partners.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer ’s disease(AD).
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
Alzheimer’s disease (AD) is a neurodegenerative disease and the main cause of dementia. Its major symptom is memory loss, which is a result of neuronal cell death, which is accompanied by neuroinflammation. Some studies indicate the overactivation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway in this disease, being, thus, a potential target for pharmacological treatment. Here, we used a transgenic mouse model of AD that expresses a mutant amyloid-β precursor protein (T41 mice) to investigate the effects of dactolisib (alternative name: NVP-BEZ23...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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