The association between the severity of chronic kidney disease and medical costs among patients with type 2 diabetes.

The association between the severity of chronic kidney disease and medical costs among patients with type 2 diabetes. J Med Econ. 2019 Feb 08;:1 Authors: Lage MJ, Boye KS, Bae JP, Wu J, Mody R, Botros FT Abstract AIMS: Examine healthcare costs across chronic kidney disease (CKD) stages for US patients with type 2 diabetes (T2D). MATERIALS AND METHODS: IQVIA Real World Data Adjudicated Claims linked electronic medical records and insurance claims from January 1, 2012 through March 31, 2017 were used for this retrospective study. Adults diagnosed with T2D and comorbid CKD were included. General linear models incorporating splines were constructed and information from these regressions were used to inform the relationship between medical costs and CKD. Multivariable analyses controlled for patient characteristics, vital signs, general health, prior medication use, prior visit to specialists, index A1c, and year of index date. RESULTS: There were 6,645 individuals who meet the study criteria. Results generally indicate sharp increases in annual total medical costs and non-drug medical costs in the 1 year post-period for patients with Stage 4 or 5 CKD (estimated glomerular filtration rate [eGFR] ≤ 30 mL/min/1.73m2) with each 1 point reduction in eGFR from 30 associated with an increase of $1,870 in all-cause total medical costs (P 
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research

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Obesity is one of the major pandemics of the 21st century. In 2013 –2014, the prevalence of obesity in the US was>35% among men and 40% among women [1]. The World Health Organization (WHO) reported that 39% of men and 39% of women were overweight, and 11% of men and 15% of women were obese in 2016. Thus, approximately 2 billion adults worldwide were overweight and, among them, more than half a billion were obese [2]. Obesity is a chronic disease adversely affecting the quality of life and is associated with many comorbidities, like hypertension, dyslipidemia, type 2 diabetes (T2DM), cardiovascular disease (CVD), n...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
In patients with type 2 diabetes mellitus and cardiovascular disease, empagliflozin (EMPA) decreased progression of chronic kidney disease, likely via a reduction in intraglomerular pressure. Due to prevalent comorbidities, such as hypertension and albuminuria, patients often receive other agents that alter intrarenal hemodynamics, including angiotensin converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARBs), calcium channel blockers and diuretics. Nonsteroidal anti-inflammatory drugs may also be used by some individuals.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Trial Source Type: research
The prevalence of type 2 diabetes (T2D) has increased rapidly in recent years, and the number of patients with T2D is expected to rise to 552 million by 2030[1]. Diabetic kidney disease (DKD), one of the most frequent complications of diabetes, is a major cause of the development and progression of chronic kidney disease and end-stage renal disease[2]. However, beyond angiotensin II-receptor blockers and angiotensin-converting enzyme inhibitors, therapeutic options to block the progression of DKD are limited and other strategies to preserve kidney function are needed[3].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
AbstractThe World Health Organization defines overweight and obesity as the condition where excess or abnormal fat accumulation increases risks to health. The prevalence of obesity is increasing worldwide and is around 20% in ICU patients. Adipose tissue is highly metabolically active, and especially visceral adipose tissue has a deleterious adipocyte secretory profile resulting in insulin resistance and a chronic low-grade inflammatory and procoagulant state. Obesity is strongly linked with chronic diseases such as type 2 diabetes, hypertension, cardiovascular diseases, dyslipidemia, non-alcoholic fatty liver disease, chr...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
To evaluate the characteristics of type 2 diabetes (T2DM) patients with or without chronic kidney disease (CKD) in Germany.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
ConclusionsWe believe this to be the first published case of a therapeutic approach to the treatment of hyperinsulinemic hypoglycemia associated with insulin antibodies that factors in blood pH and the correction of acidosis using sodium bicarbonate, which physicians could consider.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The prevalence of type 2 diabetes mellitus (T2DM) has increased dramatically in China and elsewhere [1], and T2DM is associated with a substantial increase in all-cause mortality [2]. Impaired glucose tolerance (IGT), also known as pre-diabetic state, has been shown to be a significant risk factor for T2DM. Moreover, IGT itself is significantly associated with microvascular and cardiovascular complications [3]. Studies have shown increased prevalence of retinopathy and chronic kidney disease among subjects with IGT [4,5], and reversal of IGT to normal glucose regulation has been shown to significantly reduce the risk of ca...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Objective: Long-term visit-to-visit SBP variability (VVV) has been shown to predict cerebro-cardiovascular events and end-stage renal disease in chronic kidney disease (CKD) patients. Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain. We assessed the role of SBP VVV on the development of CKD in patients with type 2 diabetes (T2D) and hypertension in real life. Methods: Clinical records from 30 851 patients with T2D and hypertension, with normal estimated glomerular filtration rate (eGFR) and regular visits during a 4-year follow-up were analyzed. SBP variability was measured b...
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research
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