Part of the brain may be 'dementia-proof'
A study by the University of Manchester found people who die from Alzheimer's produce proteins in the brain region known as the cerebellum - but not in five other key areas of the vital organ.
Condition: Dementia With Lewy Bodies Interventions: Drug: Placebo Oral Tablet; Drug: Bosutinib Oral Tablet Sponsors: Georgetown University; Alzheimer's Association Recruiting
MRI scans have identified an area of the brain associated with a rare form...Read more on AuntMinnie.comRelated Reading: Alzheimer's biomarkers could affect races differently MRI offers possible link between microbleeds, Alzheimer's New Alzheimer's definition relies on imaging biomarkers MRI measures brain atrophy in Alzheimer's Functional MRI shows how certain brain regions deteriorate with age
(University of Southern California) A USC Dornsife study comparing people with diabetes, prediabetes and normal blood sugar finds that diabetes, left untreated, could mean a higher likelihood of developing dementia, including Alzheimer's disease.
Authors: Goldfarb D, Sheard S, Shaughnessy L, Atri A Abstract Disclosing the diagnosis of cognitive impairment or dementia due to Alzheimer's disease (AD) and Related Dementias (ADRD) can be one of the most challenging aspects of dementia care for clinicians. However difficult the diagnosis is to give or receive, evidence and evidence-based consensus support that disclosing a timely AD/ADRD diagnosis, accompanied by psychoeducation and care planning, is beneficial to patient-care partner dyads. Diagnosis, provided as early as possible, increases the likelihood for patients to be involved in decision-making and plan...
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
DISCUSSION: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials. PMID: 30894299 [PubMed - as supplied by publisher]
This study aimed at evaluating brain glucose metabolism, measured by [18F]FDG-PET, in patients affected by iRBD and compared to Parkinson's Disease (PD), Lewy Body Dementia (DLB), Alzheimer's Disease (AD), and controls.
Authors: Camp CJ Abstract In far too many instances treatment of persons with dementia has reflected a fundamental denial of basic human rights. At times, these individuals are treated worse than the treatment of animals when the five basic freedoms of animals, described by Pachana in her editorial, are implemented. A number of such examples of dehumanizing (and "de-animalizing") persons with dementia are presented. A case is made for the position that this is the direct result of the "medicalization" of dementia and "Alzheimer Disease." This has led to the disenfranchisement of person...
I was a small piece in the search to find a cure. Now I feel as if I ’ m getting erased, and medical science doesn ’ t have any answers.
Conclusion: The integrated network pharmacology method provides precise probe to illuminate the molecular mechanisms of the main volatiles of WDG for relieving senile dementia related syndromes, which will also facilitate the application of traditional Chinese medicine as an alternative or supplementary to conventional treatments of AD, as well as follow-up studies such as upgrading the quality standard of clinically applied herbal medicine and novel drug development. PMID: 30891080 [PubMed]