Anti-fibrotic effect of black tea (Camellia sinensis) extract in experimental pulmonary fibrosis.

This study aims to investigate the anti-fibrotic effect of BTE against experimental pulmonary fibrosis. Four groups of animals were selected for this study. Group 1: control group mice. Group 2: mice exposed to bleomycin for 21 days, Group 3 and Group 4: bleomycin exposed mice treated with 25 mg BTE/kg b.w./day, p.o and 50 mg BTE/kg b.w./day, p.o. respectively for 21 days. Bleomycin exposed mice showed increased collagen deposition and wet/dry weight ratio, which were attenuated upon 50 mg BTE/kg b.w. treatment. The increased level of histopathological parameters in bleomycin-induced mice was significantly decreased after 50 mg BTE/kg b.w. treatment. Furthermore, 50 mg BTE/kg b.w. administration also decreased the expression of α-SMA in bleomycin-induced mice. This treatment with 50 mg BTE/kg b.w. also down regulated the expression of TGF-β and up regulated IFN-γ expression in experimental pulmonary fibrosis. The results of the present study put-forward BTE as a potential anti-fibrotic agent due to its attenuating effect on potential fibrotic markers. PMID: 30736900 [PubMed - in process]
Source: Tissue and Cell - Category: Cytology Authors: Tags: Tissue Cell Source Type: research