F.D.A. Warns Supplement Makers to Stop Touting Cures for Diseases Like Alzheimer ’ s

The agency warned 12 dietary supplement companies to stop marketing such products for disease treatments, and called for tougher regulation of the $40 billon industry.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Dietary Supplements and Herbal Remedies Drugs (Pharmaceuticals) Labeling and Labels (Product) Advertising and Marketing Regulation and Deregulation of Industry Food and Drug Administration your-feed-science Source Type: news

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Authors: Goldfarb D, Sheard S, Shaughnessy L, Atri A Abstract Disclosing the diagnosis of cognitive impairment or dementia due to Alzheimer's disease (AD) and Related Dementias (ADRD) can be one of the most challenging aspects of dementia care for clinicians. However difficult the diagnosis is to give or receive, evidence and evidence-based consensus support that disclosing a timely AD/ADRD diagnosis, accompanied by psychoeducation and care planning, is beneficial to patient-care partner dyads. Diagnosis, provided as early as possible, increases the likelihood for patients to be involved in decision-making and plan...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Publication date: Available online 23 March 2019Source: Life SciencesAuthor(s): Elizabeta Zaplatic, Muhammed Bule, Syed Zahid Ali Shah, Md. Sahab Uddin, Kamal NiazAbstractQuercetin belongs to the flavonoids family, which is present in most of the plants including fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available as a food supplement in the market and has physiological health effects. Quercetin has anti-inflammatory, anticancer and anti-prostate activities along with its beneficial effects on high cholesterol, kidney transplantation, asthma, diabetes, viral infections, pulmona...
Source: Life Sciences - Category: Biology Source Type: research
Many diseases are related to age, among these neurodegeneration is particularly important. Alzheimer's disease Parkinson's and Glaucoma have many common pathogenic events including oxidative damage, Mitochondrial dysfunction, endothelial alterations and ch...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Authors: Qi L, Cui EH, Ji CM, Zhang XB, Wang ZA, Sun YZ, Xu JC, Zhai XF, Chen ZJ, Li J, Zheng JY, Yu RT Abstract Increasing evidence emphasizes the protective role of Eph receptors in synaptic function in the pathological development of Alzheimer's disease (AD); however, their roles in the regulation of hippocampal astrocytes remain largely unknown. Here, we directly investigated the function of astroglial EphB2 on synaptic plasticity in APP/PS1 mice. Using cell isolation and transgene technologies, we first isolated hippocampal astrocytes and evaluated the expression levels of ephrinB ligands and EphB receptors. T...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Molecules, Vol. 24, Pages 1167: Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease Molecules doi: 10.3390/molecules24061167 Authors: Ştefănescu Stanciu Luca Caba Tamba Mihai Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain by ...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
CONCLUSIONS: This study reveals a role of neuroinflammation in neurodegeneration after mild blast traumatic brain injury. Therapies that target this process might in warfighters might function either by attenuating the development of post-traumatic stress disorder, chronic traumatic encephalopathy and Alzheimer's disease, or by slowing their progression. PMID: 30901455 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
DISCUSSION: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials. PMID: 30894299 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
ConclusionsThe main purpose of the current work is to focus on important topics about the microencapsulation of polyphenols, studying the specific case of the Sambucus Nigra L. extracts, including the description of the most important extraction methods for plant samples and of the encapsulation techniques and wall materials used to encapsulate polyphenols. It was also made an approach to the release tests involved in the release phenomenon of the bioactive compounds from the natural resources, including its mechanisms, simulated release media and kinetics.Graphical abstract
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
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