Choosing a First Injectable in Type 2 Diabetes: Try a GLP-1 Choosing a First Injectable in Type 2 Diabetes: Try a GLP-1

The new ADA/EASD guidelines suggest major changes in the way we manage patients with T2D. Drs Shubrook and Skolnik focus on new information about the GLP-1 receptor agonists, why to use them, and how to choose which to use.Medscape Family Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Expert Interview Source Type: news

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CONCLUSIONS: Restoring a more physiological Tie2-Ang1 axis with sildenafil reestablishes serum angiogenic properties in diabetes, promoting angiogenic homeostasis. PMID: 31102457 [PubMed - in process]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Publication date: Available online 18 May 2019Source: PeptidesAuthor(s): Allison B. Reiss, Daniel S. Glass, Eric Lam, Amy D. Glass, Joshua De Leon, Lora J. KasselmanAbstractCardiovascular disease (CVD) remains the leading cause of death worldwide, despite multiple treatment options. In addition to elevated lipid levels, oxidative stress and inflammation are key factors driving atherogenesis and CVD. New strategies are required to mitigate risk and most urgently for statin-intolerant patients. The neuropeptide hormone oxytocin, synthesized in the brain hypothalamus, is worthy of consideration as a CVD ancillary treatment be...
Source: Peptides - Category: Biochemistry Source Type: research
We describe the NAFLD-induced changes in secretion of liver proteins, lipids, other metabolites, and miRNAs, and how these molecules alter metabolism in liver, muscle, adipose tissue and pancreas to induce insulin resistance. We also synthesise the limited information which indicates that extracellular vesicles, and in particular exosomes, may be an important mechanism for inter-tissue communication in normal physiology and in promoting metabolic dysregulation in NAFLD. PMID: 31098621 [PubMed - as supplied by publisher]
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
TYPE 2 diabetes is a disease that occurs when the blood glucose level is too high. It plays havoc on one ’s health and therefore the right diet is essential to type 2 diabetics. So what is best diet for diabetics?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionsWe were able to develop an interactive estimation application to provide a population-based guidance for potential outcomes of LRYGB. This might be useful not only for health professionals but also for patients interested in learning potential outcomes in specific circumstances.
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionFindings highlight the importance of rethinking the way in which South Asians are labelled as a homogenous group and accounting for such differences when adapting and designing culturally-tailored DSME and or DSMS interventions in clinical practice.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: August 2019Source: Biomedicine &Pharmacotherapy, Volume 116Author(s): Anand P. Gupta, Pragati Singh, Richa Garg, Guru R. Valicherla, Mohammed Riyazuddin, Anees A. Syed, Zakir Hossain, Jiaur R. GayenAbstractAimsTo investigate the role of pancreastatin inhibitor (PSTi8) in lipid homeostasis and insulin sensitivity in dexamethasone induced fatty liver disease associated type 2 diabetes.Main methodsGlucose releases assay, lipid O staining and ATP/AMP ratio were performed in HepG2 cells. Twenty four mice were randomly divided into 4 groups: Control group (saline), DEX (1 mg/kg, im) for 17 days, DEX+...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study is a retrospective study based on medical records. Differences in the reactive hyperemia index (RHI) among the groups and factors affecting the RHI in each group was analyzed. The vascular endothelial function was assessed by measuring the RHI using peripheral arterial tonometry. Patients The study subjects were 114 patients with non-functional thyroid tumors (healthy n=14), T2DM (T2DM n=64), and RA (RA n=36). Results The RHI was 2.29 in the control, 1.85 in the T2DM, and 1.83 in the RA group, with values lower in the T2DM and RA groups than in the control group (p=0.033) but not markedly different between the t...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
DIABETES type 2 risk could be lowered by making some diet or lifestyle changes. You could avoid high blood sugar symptoms and signs by eating this breakfast cereal every day.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions:Women with GD history demonstrated high risk of developingT2D. Simple changes of lifestyle were shown to be an effcient prevention protocol. Despite therapeutical education, few women spontaneously complied with T2D screening. The telephone reminders could improve the screening observance therefore patient ’s outcome.Keywords:Diabetes mellitus, follow ‑up, gestational diabetes
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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