Choosing a First Injectable in Type 2 Diabetes: Try a GLP-1 Choosing a First Injectable in Type 2 Diabetes: Try a GLP-1
The new ADA/EASD guidelines suggest major changes in the way we manage patients with T2D. Drs Shubrook and Skolnik focus on new information about the GLP-1 receptor agonists, why to use them, and how to choose which to use.Medscape Family Medicine
Publication date: Available online 18 February 2019Source: Life SciencesAuthor(s): Xuyang Wang, Jinyu Pan, Hui Liu, Mingjun Zhang, Dian Liu, Lu Lu, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang AnAbstractAimsAbsent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its potential molecular mechanism.Main methodsSprague-Dawley rats were randomly divided into 4 groups: Control,...
Research, published in the Journal of Diabetes Investigation, suggests that adult type-2 diabetes patients have low natural-killer cell activity.Healio
Liang Cheng, He Zhuang, Shuo Yang, Huijie Jiang, Song Wang, Jun Zhang
DIABETES type 2 risk could be lowered by making some diet or lifestyle changes. You could prevent high blood sugar symptoms and signs by choosing to eat certain breakfast cereals. This is the best breakfast cereal to avoid diabetes symptoms.
Yun-Feng Cao, Jing Li, Zhipeng Zhang, Jinnan Liu, Xiao-Yu Sun, Xiao-Fei Feng, Hui-Huan Luo, Wen Yang, Sai-Nan Li, Xilin Yang, Zhong-Ze Fang
Previous studies in general practice and hospital settings have identified that prescribing of non-insulin diabetes medications may be sub-optimal in people with type 2 diabetes (T2D) and renal impairment. Sin...
ConclusionIn gastric bypass, creating the gastric pouch in the distal region of the stomach significantly impairs the glucose tolerance and diabetes remission in spite of the increased GLP-1 and insulin responses in T2D SD rat model, suggesting that bypassing the distal stomach may be the key mediator of early diabetes remission after RYGB.
ConclusionsNo significant differences were found in the pharmacokinetics of tramadol andO-desmethyltramadol, indicating that the opioid can be administered to overweight, obese and diabetic patients without dosage adjustment.
Publication date: Available online 16 February 2019Source: European Journal of RadiologyAuthor(s): Lequn Zhu, Zheng Xu, Guanwu Li, Ying Wang, Xuefeng Li, Xiao Shi, Haiyang Lin, Shixin ChangAbstractBackgroundMarrow fat accumulates in diabetic conditions but remains elusive. The published works on the relationships between marrow fat phenotypes and glucose homeostasis are controversial.PurposeTo detect the association of insulin resistance with marrow adiposity in postmenopausal women with newly diagnosed type 2 diabetes (T2D) using chemical shift-encoded water–fat MRI.MethodsWe measured vertebral proton density fat fr...