Cancer-stricken woman, 27, desperately tries to raise £500,000 for experimental treatment in the US

Hope Stringer, from Essex, is facing soft tissue sarcoma for the third time in five years. She was told the cancer had returned and spread weeks after she became engaged.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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AbstractThe dismal prognosis of patients with disseminated Ewing sarcoma necessitates the development of novel treatment strategies. Pazopanib is an oral multi-targeted tyrosine kinase inhibitor that is active against advanced soft tissue sarcoma. However, the clinical activity and feasibility of pazopanib for treating Ewing sarcoma remain poorly understood. Moreover, clinical information on the use of tandem high-dose chemotherapy for Ewing sarcoma is limited. A 14-year-old boy with Ewing sarcoma was transferred to our hospital for treatment. Magnetic resonance imaging, computed tomography scans, and bone scintigraphy rev...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
chi A Abstract Purpose: Pazopanib is active in soft-tissue sarcoma (STS). Because pazopanib absorption is pH-dependent, coadministration with gastric acid-suppressive (GAS) agents such as proton pump inhibitors could affect exposure of pazopanib, and thereby its therapeutic effects.Experimental Design: The EORTC 62043 and 62072 were single-arm phase II and placebo-controlled phase III studies, respectively, of pazopanib in advanced STS. We first compared the outcome of patients treated with pazopanib with or without GAS agents for ≥80% of treatment duration, and subsequently using various thresholds. The impact...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Hope Stringer, from Essex, is facing soft tissue sarcoma for the third time in five years. She was told the cancer had returned and spread weeks after she became engaged.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Our study is the first to directly compare not only clinical survival outcomes, but also late toxicities of postoperative intensity ‐modulated radiation therapy (IMRT) and two‐dimensional radiotherapy (2D‐RT) for patients with STS of extremities and trunk, and our results demonstrated that IMRT provided better local control (5 year 91.1% vs. 80.8%) and OS (5 year 90.2% vs. 81.0%) and less severe late toxicities compared wi th 2D‐RT. AbstractBackgroundTo compare the survival outcomes and late toxicities of postoperative intensity ‐modulated radiation therapy (IMRT) with two‐dimensional radiotherapy (2D‐RT) for...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
This study aimed to investigate the prognostic significance of mast cells and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1. Our results revelead an important novel finding by confirming the association of microvascular density in the tumor periphery (higher tercile,p = 0.019) with a decreased overall survival. Diverse mast cells and microvascular distributions suggest that angiogenesis occurs independently. AbstractMalignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive soft tissue sarcomas with a significant susceptibility to metastasize ear...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
This report also highlights the need for further investigation into the molecular pathophysiology of this deadly disease. PMID: 30719217 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma a...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
Leiomyosarcoma (LMS) is one of the most frequent soft tissue sarcoma subtypes and is characterized by a consistent deregulation of the PI3K/mTOR pathway. Cancer stem cells (CSCs) have been poorly studied in so...
Source: Journal of Hematology and Oncology - Category: Hematology Authors: Tags: Research Source Type: research
Opinion statementSoft tissue sarcomas are rare cancers with an expected incidence of about 14,000 new cases in 2018, and account for less than 1% of all cancers. It includes in excess of 75 heterogeneous subtypes with varying biology, molecular aberrations, and variable response to treatment. Because of the rarity of these tumors and the many different subtypes, there is no large-scale data to guide treatment, and hence the need for a multidisciplinary individualized approach to treatment, preferably at a high-volume tertiary referral center. For localized disease, surgery with or without radiation is the preferred treatme...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
An Eli Lilly treatment for advanced soft-tissue sarcoma missed the mark in a phase 3 study and will no longer be prescribed.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
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