Will the EPA finally cap toxins in water? The agency may soon announce its plan

Tiny chemical compounds called WPAs are found in non-stick products. They are now thought to be carcinogenic and widespread. They're regulated in several states and now the FDA may act.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 24 March 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Shahla Ghaderi, Samad Nejad Ebrahimi, Hamid Ahadi, Sara Eslambolchi Moghadam, Mohammad Hossein MirjaliliAbstractPerovskia abrotanoides Karel. (Lamiaceae) is an aromatic herb that is mainly grown in the mountains of Northeastern Iran across Northern Pakistan and Northwestern India. Here, a suitable system for regenerating P. abrotanoides via direct organogenesis was performed for the first time. In vitro-grown shoot tips were cultured on Murashige and Skoog (MS) medium supplemented with different concentrations (1.0...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
In this study, we attempted to achieve efficient synthesis of (S)-form 2-(hydroxymethyl)-2-methylbutanoic acid (HMMBA) from 2-ethyl-2-methyl-1,3-propanediol (EMPD) using an enzymatic approach. Agromyces sp. E2 was found to produce HMMBA from soil samples through enrichment culture using EMPD as a carbon source. The microbial asymmetric oxidation was characterized, and the highest activity was observed following addition of 0.2% (w/v) 2,2-diethyl-1,3-propanediol in the culture as an inducer. After 72 h of whole-cell incubation with 40 mM EMPD under optimized conditions, strain E2 completely converted EMPD to HMMBA with ...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
This study aimed to evaluate three heavy metal tolerant bacterial strains (HMTB) namely Alcaligenes faecalis MG257493.1, Bacillus cereus MG257494.1 and Alcaligenes faecalis MG966440.1 as antioxidant agents and plant growth promotors under laboratory conditions. Their abilities to inhibit 2,2-DiPhenyl-2-Picrylhydrazyl hydrate (DPPH) as non-enzymatic antioxidant activity and produce plant growth promoters (indole acetic acid (IAA), gibberellins (GA3), salicylic acid (SA), proline (Pro.), sidrophores, exopolysaccharide (EPS) and biosurfactant) were estimated in presence of four heavy metals Zinc (Zn2+) cadmium (Cd2+), copper ...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Authors: Künzel J, Gribko A, Lu Q, Stauber RH, Wünsch D Abstract The establishment of novel biomarkers in liquid biopsies of cancer patients comes more into focus of prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of intensive research, and are discussed as early diagnostic indicators for treatment failure and the formation of micrometastases. A potential association of this early-systemic tumor component with poor prognosis of cancer patients could be already demonstrated for various entities including breas...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
In this study we utilize two prototypic quinoxalinedione antagonists, namely DNQX and CNQX, which quench the intrinsic fluorescence of the ligand binding domain (LBD), to perform in vitro binding assays. We find that binding of DNQX and CNQX at the AMPA receptor GluA2 LBD is strongly pH dependent, whereas glutamate binding is not affected by pH. We also show that the deprotonation of DNQX, CNQX and other quinoxalinediones (NBQX and YM90K) occurs close to physiological pH, which can be explained by the lactam-lactim tautomerization of the quinoxalinedione scaffold. Analysis of our binding data indicates that quinoxalinedion...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Authors: Li Y, Sun T, Shen S, Wang L, Yan J Abstract The aim of this study was to investigate whether LncRNA DYNLRB2-2 can inhibite foam cell formation by activating autophagy. The location of DYNLRB2-2 in THP-1-derived macrophages was analyzed by fluorescence in situ hybridization. ox-LDL was used to induce the formation of foam cells, Oil Red O staining and HPLC were performed to detect accumulation of lipid dropletsand the level of cholesterol concentration, respectively. The mRNA and protein level of ABCA1 were examined by qRT-PCR and Western blotting. Relative protein levels of (p-)LKB1, (p-)AMPK, (p-)mTOR and...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Erratum for Hokynar et al., "Molecular Evidence of Chlamydia-Like Organisms in the Feces of Myotis daubentonii Bats". Appl Environ Microbiol. 2019 Apr 01;85(7): Authors: Hokynar K, Vesterinen EJ, Lilley TM, Pulliainen AT, Korhonen SJ, Paavonen J, Puolakkainen M PMID: 30902824 [PubMed - in process]
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
Several hundred University of California Davis resident physicians, fellows and interns are unionizing under the Committee of Interns and Residents branch of the Service Employees International Union.   The new union branch said Monday that a majority of its members voted to organize under CIR-SEIU. “We have successfully unionized against a backdrop of ever rising student debt, increased cost of living throughout the Sacramento region, and a health care landscape that continues to evolve,” …
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 25 March 2019Source: Molecular Aspects of MedicineAuthor(s): Heng-Huan Lee, Ying-Nai Wang, Mien-Chie HungAbstractThe human ribonuclease A (hRNase A) superfamily is comprised of 13 members of secretory RNases, most of which are recognized as catabolic enzymes for their ribonucleolytic activity to degrade ribonucleic acids (RNAs) in the extracellular space, where they play a role in innate host defense and physiological homeostasis. Interestingly, human RNases 9–13, which belong to a non-canonical subgroup of the hRNase A superfamily, are ribonucleolytic activity-deficient proteins wi...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Publication date: Available online 25 March 2019Source: Journal of Molecular StructureAuthor(s): Sung Ho Park, Sang Joon LeeAbstractMolecular interactions in Cu2+-alginate beads blended at high and low mannuronate-to-guluronate residue ratio, hereafter denoted as H-Alg and L-Alg, respectively, during the intercalation of Li+ and Mg2+ were analyzed using X-ray absorption spectroscopy. Cu2+ ions are slightly deoxidized from Cu(II) to Cu(I) after the intercalation, but their oxidation state remains as Cu(II). The lengths of Cu−O bonds are elongated and coordination numbers are more decreased in flexible conformation of ...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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