Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression

Reactive oxygen species (ROS) levels largely determine pulmonary fibrosis. Antioxidants have been found to ameliorate lung fibrosis after long-term paraquat (PQ) exposure. The effects of antioxidants, however,...

Source: BMC Pulmonary Medicine - February 11, 2019 Category: Respiratory Medicine Authors: Ming-wei Liu, Mei-xian Su, Deng-yun Tang, Li Hao, Xiang-Han Xun and Yun-qiao Huang Tags: Research article Source Type: research