Half a Million Breast Cancer Deaths Avoided in Last 30 Years As a Result of Improved Treatment and Screening Half a Million Breast Cancer Deaths Avoided in Last 30 Years As a Result of Improved Treatment and Screening

During the past 30 years a combination of screening and improved treatments have reduced the mortality rate from breast cancer, but it is unclear which had the larger impact.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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Publication date: Available online 23 March 2019Source: European Journal of Surgical OncologyAuthor(s): Paul Savage, Nancy Yu, Sinziana Dumitra, Sarkis MeterissianAbstractIntroductionBreast cancer staging has been developed to quantify prognosis and guide treatment. The American Joint Committee on Cancer eighth edition manual (AJCC8) departed from traditional anatomic staging by incorporating biological factors such as grade, hormone and HER2 receptor status into a novel prognostic staging model. The aim of this study was to externally validate AJCC8 prognostic staging.MethodsThis retrospective cohort investigated patients...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Authors: Hao JQ, Zhang QK, Zhou YX, Chen LH, Wu PF Abstract Introduction: The aim of this meta-analysis was to summarize the evidence on the serum/plasma leptin concentrations in breast cancer (BC) patients, as well as the associations between leptin G-2548A gene polymorphisms and susceptibility to BC. Material and methods: Potentially relevant studies about serum/plasma leptin levels and leptin G-2548A gene polymorphism were selected using the electronic databases PubMed, EMBASE and The Cochrane Library (from January 1 1995 to Jun 30 2017, no language restrictions). The potential sources of heterogeneity were ...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Publication date: Available online 23 March 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Aqsa Habib, Mansoureh Nazrai Vishkaei, Muhammad Adnan Iqbal, Haq Nawaz Bhatti, M.B. Khadeer Ahmed, A.M.S. Abdul MajidAbstractThe promising biomedical applications of silver complexes stimulated the researchers to test these compounds against cancer. The present research work was designed to achieve this goal. In this work, a series of 5-methyl benzimidazole based N-Heterocyclic carbene ligands and respective silver(I) complexes were synthesized and tested on cancer cell lines to assess their anticancer activity. Unsymmetrica...
Source: Journal of Saudi Chemical Society - Category: Chemistry Source Type: research
ConclusionLipofilling is a very useful tool that could help in cases of an uninfected exposed implant. It could also be used primarily as an adjunct procedure to implant based reconstruction to optimize the outcome.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: 23–29 March 2019Source: The Lancet, Volume 393, Issue 10177Author(s): Stephanie Lheureux, Charlie Gourley, Ignace Vergote, Amit M OzaSummaryEpithelial ovarian cancer generally presents at an advanced stage and is the most common cause of gynaecological cancer death. Treatment requires expert multidisciplinary care. Population-based screening has been ineffective, but new approaches for early diagnosis and prevention that leverage molecular genomics are in development. Initial therapy includes surgery and adjuvant therapy. Epithelial ovarian cancer is composed of distinct histological subtypes with u...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: June 2019Source: Biomedicine &Pharmacotherapy, Volume 114Author(s): Lansheng Zhang, Yanwei Chen, Caihong Li, Jinyang Liu, Huiwen Ren, Lishan Li, Xia Zheng, Hui Wang, Zhengxiang HanAbstractOthers and ours studies have established the promoting roles of NRP-1 (neuropilin-1) in breast cancer, however, the underlying mechanisms by which NRP-1 is regulated are still confused. Here, bioinformatics analysis indicated that RNA binding protein PUM2 could bind to NRP-1 mRNA. Clinical samples showed that PUM2 expression was significantly increased in breast cancer tissues, negatively correlated with the overall ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Abstract Selective estrogen receptor modulators (SERMs) are synthetic non-steroidal agents which have variable estrogen agonist and antagonist activities in different target tissues. Tamoxifen is an anti-estrogen in the breast used for treatment and prevention of breast cancer, with estrogen agonist activity in the uterus. Raloxifene prevents and treats osteoporosis and prevents breast cancer, and can be safely combined with vaginal but not systemic estrogen. The tissue selective estrogen complex combines conjugated equine estrogens (CEE) with the SERM bazedoxifene (BZA). The five Selective Estrogen Menopause and ...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
CONCLUSION:: This study confirms the need for an axillary exploration for these tumors even for a tumor size
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
In this study, we attempted to identify the race-specific non-invasive protein biomarkers that may particularly benefit interventions aimed at reducing the risk of recurrence and metastasis in breast cancers (BrCa). Our technical strategy has been to discover candidate protein biomarkers in patient sera using a high throughput antibody microarray platform. A total of 240 subjects were selected, composed of controls and all immunohistochemistry-based subtypes of breast cancer cases, subdivided by pre- and post-menopausal status and by race. A global Wilcoxon analysis comparing no-cancer controls and cancer patients identifi...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Shi R, Wang C, Fu N, Liu L, Zhu D, Wei Z, Zhang H, Xing J, Wang Y Abstract Multiple drug resistance (MDR) and metastasis have been identified as the two major causes of the poor prognosis of patients with breast cancer. However, the relationship between MDR and metastasis has not been characterized. Epithelial‑mesenchymal transition (EMT), a process known to promote metastasis in cancer, has been shown to be associated with the MDR phenotype of many tumor types. Reduced cytokeratin 18 (CK18) expression is thought to be one of the hallmarks of EMT, and the role of CK18 in MDR of metastatic breast cancer r...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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